Evidence map›Paper›PMID 28848319›Full record

ArticleMolecular vision2017

Magnetic resonance imaging study of eye congenital birth defects in mouse model.

Jing-Huei Lee, Zachary Tucker, Maureen Mongan, Qinghang Meng, Ying Xia

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Molecular vision, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jing-Huei LeeDepartment of Biomedical Engineering, College of Engineering and Applied Science, University of Cincinnati, OH.
Zachary TuckerDepartment of Biomedical Engineering, College of Engineering and Applied Science, University of Cincinnati, OH.
Maureen MonganDepartment of Environmental Health, College of Medicine, University of Cincinnati, OH.
Qinghang MengDepartment of Environmental Health, College of Medicine, University of Cincinnati, OH.
Ying XiaDepartment of Environmental Health, College of Medicine, University of Cincinnati, OH.
University of Cincinnati Medical Center · US

Funding

The Role of MAP 3 Kinase 1 in Ocular Surface MorphogenesisR01EY015227 · NEI · UNIVERSITY OF CINCINNATI · PI XIA, YING · 2004 to 2019
$5.4M
NEI NIH HHS R01 EY015227
6 · The paper itself

Abstract

purposeEmbryonic eyelid closure is a well-documented morphogenetic episode in mammalian eye development. Detection of eyelid closure defect in humans is a major challenge because eyelid closure and reopen occur entirely in utero. As a consequence, congenital eye defects that are associated with failure of embryonic eyelid closure remain unknown. To fill the gap, we developed a mouse model of defective eyelid closure. This preliminary work demonstrates that the magnetic resonance imaging (MRI) approach can be used for the detection of extraocular muscle abnormalities in the mouse model.

methodsMice with either normal (

resultsIn agreement with histological findings, the imaging data show that mice with defective embryonic eyelid closure develop less extraocular muscle than normal mice. In addition, the size of the eyeballs was noticeably reduced in mice with defective embryonic eyelid closure.

conclusionsWe demonstrated that MRI can potentially be used for the study of extraocular muscle in the mouse model of the eye open-at-birth defect, despite the lack of specificity of muscle group provided by the current imaging resolution.

Indexed as

Disease Models, AnimalMagnetic Resonance ImagingAnimalsEye AbnormalitiesEyelid DiseasesFemaleMiceMice, Inbred C57BLMice, KnockoutOculomotor Muscles

Identifiers

PMID28848319
PMCPMC5561137
OpenAlexW2742892664

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.