Evidence map›Paper›PMID 28848246›Full record

ReviewMediators of inflammation2017

Advances in Immunotherapy for Melanoma: A Comprehensive Review.

Carmen Rodríguez-Cerdeira, Miguel Carnero Gregorio, Adriana López-Barcenas, Elena Sánchez-Blanco, Beatriz Sánchez-Blanco, Gabriella Fabbrocini, Brunilda Bardhi, Ardiana Sinani, Roberto Arenas Guzman

Open access · goldAbstract readReview
In one paragraph

Review in Mediators of inflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 142 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 4 countries.

Carmen Rodríguez-CerdeiraDermatology Service, Hospital do Meixoeiro and University of Vigo, Vigo, Spain.ORCID 0000-0001-9939-0771
Miguel Carnero GregorioDepartment of Biochemistry, Genetics and Immunology, University of Vigo, Vigo, Spain.
Adriana López-BarcenasMycology Service, Hospital Manuel Gea González, Mexico City, Mexico.
Elena Sánchez-BlancoHealth Department, Xunta Galicia, Vigo, Spain.
Beatriz Sánchez-BlancoGalician Healthcare Service, Vigo, Spain.
Gabriella FabbrociniDermatology Service, University of Napoli Federico II, Naples, Italy.
Brunilda BardhiDermatology Service, Venus Clinic, Tirana, Albania.
Ardiana SinaniDermatology Service, Military Medical Unit, University Trauma Hospital, Tirana, Albania.
Roberto Arenas GuzmanMycology Service, Hospital Manuel Gea González, Mexico City, Mexico.ORCID 0000-0002-2992-9564
Hospital General Dr. Manuel Gea Gonzalez · MXUniversidade de Vigo · ESUniversity Hospital Complex Of Vigo · ESUniversity of Medicine Tirana · ALUniversity of Naples Federico II · ITXunta de Galicia · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Melanomas are tumors originating from melanocytes and tend to show early metastasis secondary to the loss of cellular adhesion in the primary tumor, resulting in high mortality rates. Cancer-specific active immunotherapy is an experimental form of treatment that stimulates the immune system to recognize antigens on the surface of cancer cells. Current experimental approaches in immunotherapy include vaccines, biochemotherapy, and the transfer of adoptive T cells and dendritic cells. Several types of vaccines, including peptide, viral, and dendritic cell vaccines, are currently under investigation for the treatment of melanoma. These treatments have the same goal as drugs that are already used to stimulate the proliferation of T lymphocytes in order to destroy tumor cells; however, immunotherapies aim to selectively attack the tumor cells of each patient. In this comprehensive review, we describe recent advancements in the development of immunotherapies for melanoma, with a specific focus on the identification of neoantigens for the prediction of their elicited immune responses. This review is expected to provide important insights into the future of immunotherapy for melanoma.

Indexed as

Cancer VaccinesDendritic CellsHumansImmunotherapyMelanomaT-LymphocytesCancer Vaccines

Identifiers

PMID28848246
PMCPMC5564072
OpenAlexW2741790433

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.