Evidence map›Paper›PMID 28848142›Full record

ArticleHormone research in paediatrics2017

Brain Malformations Do Not Predict Hypopituitarism in Young Children with Optic Nerve Hypoplasia.

Pamela Garcia-Filion, Hashem Almarzouki, Cassandra Fink, Mitchell Geffner, Marvin Nelson, Mark Borchert

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hormone research in paediatrics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Pamela Garcia-FilionThe Vision Center, Children's Hospital Los Angeles, Los Angeles, California, USA.
Hashem AlmarzoukiDepartment of Ophthalmology, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia.
Cassandra FinkThe Vision Center, Children's Hospital Los Angeles, Los Angeles, California, USA.
Mitchell GeffnerDepartment of Endocrinology, Diabetes, and Metabolism, Children's Hospital Los Angeles, Los Angeles, California, USA.
Marvin NelsonDepartment of Radiology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Mark BorchertThe Vision Center, Children's Hospital Los Angeles, Los Angeles, California, USA.
Children's Hospital of Los Angeles · USKing Saud bin Abdulaziz University for Health Sciences · SA

Funding

Southern California Clinical and Translational Science InstituteUL1TR001855 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Thomas A Buchanan, Michele D. Kipke · 2016 to 2026
$81.3M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1 TR001855
6 · The paper itself

Abstract

backgroundOptic nerve hypoplasia (ONH), a leading cause of pediatric blindness, is associated with brain malformations and hypopituitarism in the constellation known as septo-optic dysplasia. Neuroimaging is used to anticipate hypopituitarism, but with unconfirmed reliability. We report prospective findings on the association of hypopituitarism with brain malformations.

methodsChildren (<24 months) with ONH (n = 146; 87% bilateral) underwent baseline MRI and annual examinations and hormonal testing. Hypopituitarism status at age 5 years was classified.

resultsA total of 74% had brain malformation(s). Hypopituitarism (69%) was not associated with brain malformations (p = 0.351); this persisted after adjusting for the laterality of ONH and the timing of MRI (padj = 0.869). No association was noted for absent septum pellucidum (38%; p = 0.073), corpus callosum abnormality (51%; p = 0.625), and major malformations (22%; p = 0.407). A malformation conferred a positive predictive value of 71% (95% CI: 62%, 80%), and a negative predictive value of 37% (95% CI: 22%, 54%). Overall, 10% (n = 15) of the cohort presented with a triad of absent septum pellucidum, corpus callosum abnormality, and other major malformation; only half (n = 8) of these had hypopituitarism. All 13 subjects with pituitary malformations manifested hypopituitarism, conferring predictive values of 100% (positive) and 34% (negative).

conclusionsHypopituitarism and brain malformations are highly prevalent, but have unrelated associations with ONH. Brain MRI in infants and toddlers with ONH is an unreliable screen for hypopituitarism risk.

Indexed as

Child, PreschoolFemaleHumansHypopituitarismInfantMagnetic Resonance ImagingMaleMalformations of Cortical DevelopmentOptic Nerve DiseasesProspective StudiesCerebral malformationHypopituitarismOptic nerve hypoplasiaPituitary glandSepto-optic dysplasia

Identifiers

PMID28848142
PMCPMC5647222
OpenAlexW2750545374

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.