ArticleAudiology & neuro-otology2017
Histopathology of the Human Inner Ear in the Cogan Syndrome with Cochlear Implantation.
Article in Audiology & neuro-otology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 14 citations in OpenAlex.
- Cogan's syndrome is more than just keratitis: a case-based literature review.BMC ophthalmology · 2023Article
- Cochlear Implantation and Perioperative Management in Autoimmune Inner Ear Disease: A Systematic Review and Meta-Analysis.Otology & neurotology open · 2021Article
- Hearing loss in inner ear and systemic autoimmune disease: A systematic review of post-cochlear implantation outcomes.Laryngoscope investigative otolaryngology · 2021Review
- Meta-Analysis-Correlation between Spiral Ganglion Cell Counts and Speech Perception with a Cochlear Implant.Audiology research · 2021Review
- [Immune-mediated sensorineural hearing loss: prevalence and treatment strategies].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Cogan syndrome is a rare disorder characterized by nonsyphilitic interstitial keratitis and audiovestibular symptoms. Profound sensorineural hearing loss has been reported in approximately half of the patients with the Cogan syndrome resulting in candidacy for cochlear implantation in some patients. The current study is the first histopathologic report on the temporal bones of a patient with the Cogan syndrome who during life underwent bilateral cochlear implantation. Preoperative MRI revealed tissue with high density in the basal turns of both cochleae and both vestibular systems consistent with fibrous tissue due to labyrinthitis. Histopathology demonstrated fibrous tissue and new bone formation within the cochlea and vestibular apparatus, worse on the right. Severe degeneration of the vestibular end organs and new bone formation in the labyrinth were seen more on the right than on the left. Although severe bilateral degeneration of the spiral ganglion neurons was seen, especially on the right, the postoperative word discrimination score was between 50 and 60% bilaterally. Impedance measures were generally higher in the right ear, possibly related to more fibrous tissue and new bone found in the scala tympani on the right side.
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Registered trials
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