Evidence map›Paper›PMID 28848053›Full record

ArticleCancer immunology research2017

Antigen-Presenting Intratumoral B Cells Affect CD4

Tullia C Bruno, Peggy J Ebner, Brandon L Moore, Olivia G Squalls, Katherine A Waugh, Evgeniy B Eruslanov, Sunil Singhal, John D Mitchell, Wilbur A Franklin, Daniel T Merrick and 4 more

Open access · greenAbstract read
In one paragraph

Article in Cancer immunology research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 197 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
197citing papers in PubMed, 1 pooled it
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

197 citing papers in PubMed, 1 synthesis or guideline pooled it, 296 citations in OpenAlex.

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137 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Tullia C BrunoDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.
Peggy J EbnerDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.
Brandon L MooreDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.
Olivia G SquallsDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.
Katherine A WaughDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado.
Evgeniy B EruslanovDivision of Thoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
Sunil SinghalDivision of Thoracic Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.
John D MitchellDepartment of Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Wilbur A FranklinDepartment of Pathology, University of Colorado School of Medicine, Aurora, Colorado.
Daniel T MerrickDepartment of Pathology, University of Colorado School of Medicine, Aurora, Colorado.
Martin D McCarterDepartment of Surgery, University of Colorado School of Medicine, Aurora, Colorado.
Brent E PalmerDivision of Allergy and Clinical Immunology, University of Colorado School of Medicine, Aurora, Colorado.
Jeffrey A KernDivision of Oncology, National Jewish Health, Denver, Colorado.
Jill E SlanskyDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado. jill.slansky@ucdenver.edu.
University of Colorado Denver · USUniversity of Pennsylvania · USNational Jewish Health · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
Tissue Bank and Biomarkers CoreP50CA058187 · NCI · UNIVERSITY OF COLORADO DENVER · PI NEMENOFF, RAPHAEL A. · 1992 to 2018
$43.8M
TRAINING PROGRAM IN MUSCULOSKELETAL RESEARCHT32AR007505 · NIAMS · CASE WESTERN RESERVE UNIVERSITY · PI TRIOLO, RONALD J · 1986 to 2023
$6.3M
Tumor-associated neutrophils in human lung cancerR01CA187392 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERUSLANOV, EVGENIY · 2016 to 2020
$1.8M
NCATS NIH HHS UL1 TR001082NCI NIH HHS P30 CA046934NCI NIH HHS P50 CA058187NCI NIH HHS R01 CA187392NIAMS NIH HHS T32 AR007505
6 · The paper itself

Abstract

Effective immunotherapy options for patients with non-small cell lung cancer (NSCLC) are becoming increasingly available. The immunotherapy focus has been on tumor-infiltrating T cells (TILs); however, tumor-infiltrating B cells (TIL-Bs) have also been reported to correlate with NSCLC patient survival. The function of TIL-Bs in human cancer has been understudied, with little focus on their role as antigen-presenting cells and their influence on CD4

Indexed as

AgedAged, 80 and overAntigen PresentationAntigen-Presenting CellsBiomarkersB-LymphocytesCarcinoma, Non-Small-Cell LungCD4-Positive T-LymphocytesFemaleHumansImmunophenotypingLung NeoplasmsLymphocyte ActivationLymphocyte CountLymphocytes, Tumor-InfiltratingMaleBiomarkers

Identifiers

PMID28848053
PMCPMC5788174
OpenAlexW2747207966

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.