Evidence map›Paper›PMID 28848022›Full record

ArticleAntimicrobial agents and chemotherapy2017

Pharmacological Basis of CD101 Efficacy: Exposure Shape Matters.

Elizabeth A Lakota, Justin C Bader, Voon Ong, Ken Bartizal, Lynn Miesel, David R Andes, Sujata M Bhavnani, Christopher M Rubino, Paul G Ambrose, Alexander J Lepak

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Treatment Outcomes Among Patients With a Positive Candida Culture Close to Randomization Receiving Rezafungin or Caspofungin in the ReSTORE Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Trial
  3. Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Trial
  4. Review
  5. Rezafungin for the treatment of invasive candidiasis secondary to esophagogastric anastomotic leak: clinical success in a complex situation.Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2026
    Article
  6. Successful rezafungin treatment of an azole-resistantRevista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2025
    Article
  7. Review
  8. New Perspectives on Antimicrobial Agents: Rezafungin.Antimicrobial agents and chemotherapy · 2025
    Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Therapeutic Approaches for CombatingCurrent drug targets · 2022
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Elizabeth A LakotaInstitute for Clinical Pharmacodynamics (ICPD), Schenectady, New York, USA elakota@icpd.com.
Justin C BaderInstitute for Clinical Pharmacodynamics (ICPD), Schenectady, New York, USA.
Voon OngCidara Therapeutics, San Diego, California, USA.
Ken BartizalCidara Therapeutics, San Diego, California, USA.
Lynn MieselEurofins Panlabs, Ltd., St. Charles, Missouri, USA.
David R AndesUniversity of Wisconsin-Madison, Madison, Wisconsin, USA.
Sujata M BhavnaniInstitute for Clinical Pharmacodynamics (ICPD), Schenectady, New York, USA.
Christopher M RubinoInstitute for Clinical Pharmacodynamics (ICPD), Schenectady, New York, USA.
Paul G AmbroseInstitute for Clinical Pharmacodynamics (ICPD), Schenectady, New York, USA.
Alexander J LepakUniversity of Wisconsin-Madison, Madison, Wisconsin, USA.
Institute for Clinical Pharmacodynamics (United States) · USCidara Therapeutics (United States) · USUniversity of Wisconsin–Madison · USEurofins (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CD101 is a novel echinocandin with concentration-dependent fungicidal activity

Indexed as

EchinocandinsAnimalsAntifungal AgentsCandida albicansCandidiasisDisease Models, AnimalDrug Administration ScheduleHumansMiceMice, Inbred ICRMicrobial Sensitivity TestsAntifungal AgentsCD101 echinocandinEchinocandinsechinocandinexposure shapepharmacokinetics/pharmacodynamicsPK/PDsingle dose

Identifiers

PMID28848022
PMCPMC5655053
OpenAlexW2749642217

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.