Evidence map›Paper›PMID 28847951›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2017

Shear force-based genetic screen reveals negative regulators of cell adhesion and protrusive activity.

Thomas J Lampert, Nadine Kamprad, Marc Edwards, Jane Borleis, Ayende J Watson, Marco Tarantola, Peter N Devreotes

Erratum issuedOpen access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Adhesion ofFrontiers in cell and developmental biology · 2022
    Review
  9. Cellular inertia.Scientific reports · 2021
    Article
  10. Using Live-Cell Imaging and Synthetic Biology to Probe Directed Migration inFrontiers in cell and developmental biology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Statin-induced GGPP depletion blocks macropinocytosis and starves cells with oncogenic defects.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Insight from the maximal activation of the signal transduction excitable network inProceedings of the National Academy of Sciences of the United States of America · 2018
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Thomas J LampertDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD21286.
Nadine KampradMax Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Marc EdwardsDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD21286.
Jane BorleisDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD21286.
Ayende J WatsonDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD21286.
Marco TarantolaMax Planck Institute for Dynamics and Self-Organization, 37077 Göttingen, Germany.
Peter N DevreotesDepartment of Cell Biology, Johns Hopkins University School of Medicine, Baltimore, MD21286; pnd@jhmi.edu.
Johns Hopkins University · USJohns Hopkins Medicine · USMax Planck Institute for Dynamics and Self-Organization · DE

Funding

Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
Temporal and Spatial Signaling in ChemotaxisR01GM034933 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 1987 to 2015
$8.8M
SIGNAL TRANSDUCTION AND DICTYOSTELIUM DEVELOPMENTR01GM028007 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI DEVREOTES, PETER N · 1985 to 2004
$2.4M
NIGMS NIH HHS R01 GM028007NIGMS NIH HHS R01 GM034933NIGMS NIH HHS R35 GM118177
6 · The paper itself

Abstract

The model organism

Indexed as

Actin CytoskeletonActinsCell AdhesionCell MovementChemotaxisCyclic AMPCytoskeletonDictyosteliumGenetic TestingProtozoan ProteinsShear StrengthSignal TransductionActinsCyclic AMPProtozoan Proteinscell adhesioncell migrationchemotaxisDictyosteliumPTEN

Identifiers

PMID28847951
PMCPMC5603988
OpenAlexW2750399741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.