ArticleProceedings of the National Academy of Sciences of the United States of America2017
Surveying the sequence diversity of model prebiotic peptides by mass spectrometry.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Stringent selection on kinetics of condensation reactions: early steps in chemical evolution.Physical chemistry chemical physics : PCCP · 2026Article
- Depsipeptide Analogues of Gly-Ala-Gly: Proton Localization and Effects on Collision-Induced Dissociation.Journal of the American Society for Mass Spectrometry · 2026Article
- Sample Preparation for MALDI-TOF Mass Spectrometry of Model Prebiotic Reactions in Simulated Ocean World Environments.ACS omega · 2025Article
- Protopeptide backbone affects assembly in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Developing a Mass Spectrometry-Based Research and Teaching Program at a Primarily Undergraduate Institution.Journal of the American Society for Mass Spectrometry · 2025Review
- Evolution of complex chemical mixtures reveals combinatorial compression and population synchronicity.Nature chemistry · 2025Article
- Biological Polymers: Evolution, Function, and Significance.Accounts of chemical research · 2025Article
- Probing the Limits of Reactant Concentration and Volume in Primitive Polyphenyllactate Synthesis and Microdroplet Assembly Processes.ACS bio & med chem Au · 2025Article
- Catalytic peptide/hemin complex from ester-amide exchange reaction mediated by deep eutectic solvents.RSC advances · 2025Article
- Optical Recognition of the English Alphabet Using Proteinoids.ACS omega · 2024Article
- From Catalysis of Evolution to Evolution of Catalysis.Accounts of chemical research · 2024Article
- Qualitative Monitoring of Proto-Peptide Condensation by Differential FTIR Spectroscopy.ACS earth & space chemistry · 2024Article
- Amino acid analogues provide multiple plausible pathways to prebiotic peptides.Journal of the Royal Society, Interface · 2024Review
- Electron transport chains as a window into the earliest stages of evolution.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Distinguishing Biotic vs. Abiotic Origins of 'Bio'signatures: Clues from Messy Prebiotic Chemistry for Detection of Life in the Universe.Life (Basel, Switzerland) · 2023Article
- Recent progress in primitive polyester synthesis and membraneless microdroplet assembly.Biophysics and physicobiology · 2023Article
- Supramolecular systems chemistry through advanced analytical techniques.Analytical and bioanalytical chemistry · 2022Review
- Article
- Differential Oligomerization of Alpha versus Beta Amino Acids and Hydroxy Acids in Abiotic Proto-Peptide Synthesis Reactions.Life (Basel, Switzerland) · 2022Article
- Toward Molecular Cooperation by De Novo Peptides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The rise of peptides with secondary structures and functions would have been a key step in the chemical evolution which led to life. As with modern biology, amino acid sequence would have been a primary determinant of peptide structure and activity in an origins-of-life scenario. It is a commonly held hypothesis that unique functional sequences would have emerged from a diverse soup of proto-peptides, yet there is a lack of experimental data in support of this. Whereas the majority of studies in the field focus on peptides containing only one or two types of amino acids, here we used modern mass spectrometry (MS)-based techniques to separate and sequence de novo proto-peptides containing broader combinations of prebiotically plausible monomers. Using a dry-wet environmental cycling protocol, hundreds of proto-peptide sequences were formed over a mere 4 d of reaction. Sequence homology diagrams were constructed to compare experimental and theoretical sequence spaces of tetrameric proto-peptides. MS-based analyses such as this will be increasingly necessary as origins-of-life researchers move toward systems-level investigations of prebiotic chemistry.
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