ArticleProceedings of the National Academy of Sciences of the United States of America2017
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers.
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90citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
What it found
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Who cites it
90 citing papers in PubMed, 150 citations in OpenAlex.
- Whole exome sequencing of paediatric patients with Cogan's syndrome to identify monogenic mimics.Rheumatology (Oxford, England) · 2026Article
- Hyperuricemia beyond gout: an emerging risk factor for sensorineural hearing loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Genetic Findings in Seven Cochlear Implanted Patients with Severe-to-Profound Hearing Loss.Genes · 2026Article
- A neurologist's guide to VEXAS syndrome: Differentiating somatic autoinflammation from autoimmune mimics.Intractable & rare diseases research · 2026Review
- Therapeutic Potential of 1‑(1,2,3,5,6,7-Hexahydro‑ACS pharmacology & translational science · 2026Article
- The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities.MedComm · 2026Review
- ZNF334 truncation mutation drives cold-induced autoinflammation.EMBO molecular medicine · 2025Article
- NLRP3 inflammasome and hearing loss: from mechanisms to therapies.Journal of neuroinflammation · 2025Review
- Targeting NLRP3/caspase-1/GSDMD to treat inner ear injury from labyrinthine hemorrhage.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Article
- Advances in the Study of NOD-Like Receptors in Common Otological Diseases.The journal of international advanced otology · 2025Review
- The expanding role of the NLRP3 inflammasome from periodic fevers to therapeutic targets.Nature immunology · 2025Review
- Targeting Programmed Cell Death in Acquired Sensorineural Hearing Loss: Ferroptosis, Necroptosis, and Pyroptosis.Neuroscience bulletin · 2025Review
- Angiotensin-Receptor Blockers Prevent Vestibular Schwannoma-Associated Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2025Article
- Chronic suppurative otitis media: disrupted host-microbial interactions and immune dysregulation.Frontiers in immunology · 2025Review
- A Selection Protocol to Identify Therapeutics to Target NLRP3-Associated Sensory Hearing Loss.Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology · 2024Article
- Targeting the NLRP3 inflammasome in cochlear macrophages protects against hearing loss in chronic suppurative otitis media.Journal of neuroinflammation · 2024Article
- Functional pathogenicity of ESRRB variant of uncertain significance contributes to hearing loss (DFNB35).Scientific reports · 2024Article
- Activated tissue-resident macrophages contribute to hair cell insults in noise-induced hearing loss in mice.Communications biology · 2024Article
- Implication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome.Cells · 2024Review
- A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment.Antioxidants (Basel, Switzerland) · 2024Review
30 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 3 institutions in 1 country.
Hiroshi NakanishiOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Yoshiyuki KawashimaOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Kiyoto KurimaOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Jae Jin ChaeInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Astin M RossOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Gineth Pinto-PatarroyoInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Seema K PatelRheumatology Fellowship and Training Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892.
Julie A MuskettOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Jessica S RatayOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Parna ChattarajOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Yong Hwan ParkInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Sriharsha GrevichRady Children's Hospital and Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.
Carmen C BrewerOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
Michael HoaOffice of the Clinical Director, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
H Jeffrey KimOffice of the Clinical Director, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892.
John A ButmanRadiology and Imaging Sciences, Clinical Center, National Institutes of Health, Bethesda, MD 20892.ORCID 0000-0002-1547-9195
Lori BroderickRady Children's Hospital and Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.
Hal M HoffmanRady Children's Hospital and Department of Pediatrics, University of California, San Diego, La Jolla, CA 92093.
Ivona AksentijevichInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892.
Daniel L KastnerInflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892; kastnerd@mail.nih.gov griffita@nidcd.nih.gov.
Raphaela Goldbach-ManskyTranslational Autoinflammatory Disease Studies, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892.
Andrew J GriffithOtolaryngology Branch, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD 20892; kastnerd@mail.nih.gov griffita@nidcd.nih.gov.
National Institutes of Health · USUniversity of California San Diego · USNational Institutes of Health Clinical Center · US
Funding
Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Stills-like Diseases, and other Undifferentiated Autoinflammatory DiseasesZIAAI001220 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2017 to 2025
$22.3MMolecular Analysis Of Human Hereditary DeafnessZIADC000060 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI ROUX, ISABELLE · 2009 to 2022
$18.4MCellular and Molecular Pathways for Hearing Restoration in the Adult Inner EarZIADC000088 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI HOA, MICHAEL · 2015 to 2025
$14.0MMolecular Analysis Of Human Hereditary DeafnessZ01DC000060 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI GRIFFITH, ANDREW J · 2001 to 2008
$3.0MPathogenesis and treatment studies in patients with NOMID and related diseasesZ01AR041138 · NIAMS · NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES · PI GOLDBACH-MANSKY, RAPHAELA · 2003 to 2008
$2.3MClinical Analysis Of Disorders Of Hearing And BalanceZ01DC000064 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI GRIFFITH, ANDREW J · 2001 to 2008
$1.2MNIDCD Core for Clinical Research and CareZ01DC000075 · NIDCD · NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS · PI VAN WAES, CARTER · 2008 to 2008
$1.1MMolecular Genetics and Immunoregulatory mechanisms of PFAPA syndromeK08HD075830 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRODERICK, LORI · 2014 to 2018
$769kIntramural NIH HHS Z01 AR041138Intramural NIH HHS Z01 DC000060Intramural NIH HHS Z01 DC000064Intramural NIH HHS Z01 DC000075NICHD NIH HHS K08 HD075830
Abstract
The NLRP3 inflammasome is an intracellular innate immune sensor that is expressed in immune cells, including monocytes and macrophages. Activation of the NLRP3 inflammasome leads to IL-1β secretion. Gain-of-function mutations of
Indexed as
AdultAnimalsBase SequenceCarrier ProteinsCochleaCryopyrin-Associated Periodic SyndromesDeafnessFamilyFemaleHearing LossHearing Loss, SensorineuralHumansInflammasomesInflammationInterleukin-1betaInterleukin 1 Receptor Antagonist ProteinCarrier ProteinsInflammasomesInterleukin-1betainterleukin-1beta (163-171)Interleukin 1 Receptor Antagonist ProteinNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, humanNlrp3 protein, mousePeptide Fragmentscochleacryopyrin-associated periodic syndromeshearing lossinflammationinterleukin-1β
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What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.