ArticleJournal of the American Heart Association2017
Vulnerabilities to Health Disparities and Statin Use in the REGARDS (Reasons for Geographic and Racial Differences in Stroke) Study.
Article in Journal of the American Heart Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Safety and Efficacy of Inclisiran in Hyperlipidemia: An Updated Meta-Analysis of Randomised Controlled Trials.Endocrinology, diabetes & metabolism · 2025Pooled it
- Impact of removing prescription co-payments on the use of costly health services: a pragmatic randomised controlled trial.BMC health services research · 2023Trial
- Gaps in lipid screening and statin use among uninsured patients in a charitable community clinic.American journal of preventive cardiology · 2026Article
- Trends in the Association of Neighborhood Socioeconomic Status With Stroke Incidence and Mortality From 2000 to 2022: A Population-Based Study.Journal of the American Heart Association · 2026Article
- SDoH-GPT: using large language models to extract social determinants of health.Journal of the American Medical Informatics Association : JAMIA · 2026Article
- Improving Representation of Underserved Populations in Cardiovascular Research.Journal of the American Heart Association · 2025Review
- Disparities in statin use following identification of coronary artery calcium.American journal of preventive cardiology · 2025Article
- Examining Healthy Lifestyles as a Mediator of the Association Between Socially Determined Vulnerabilities and Incident Heart Failure.Circulation. Cardiovascular quality and outcomes · 2025Article
- Systemic Statin Use and Pulp Chamber Calcification: A Pilot Retrospective Case-Control Study Using Cone-Beam Computed Tomography.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025Article
- Racial and ethnic disparities in statin adherence: insights from the All of Us Research Program.Frontiers in cardiovascular medicine · 2025Article
- Statin utilization and its predictors for the primary prevention of cardiovascular disease among type 2 diabetic patients in a resource-limited setting.Frontiers in endocrinology · 2025Article
- Unveiling the link: social determinants of health, quality of life, and burden of treatment in heart failure patients.American journal of cardiovascular disease · 2025Article
- National-level and state-level prevalence of overweight and obesity among children, adolescents, and adults in the USA, 1990-2021, and forecasts up to 2050.Lancet (London, England) · 2024Article
- Social Determinants of Health and Cardiovascular Risk among Adults with Diabetes: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study.Diabetes & metabolism journal · 2024Article
- Impact of Guideline-Directed Statin Prescriptions on Cardiovascular Outcomes by Race in a Real-World Primary Prevention Cohort.JACC. Advances · 2024Article
- Article
- Primary Prevention for Intermediate Risk: The More Things Change, the More They Stay the Same.JACC. Advances · 2024Article
- Association Between Pharmacy Proximity With Cardiovascular Medication Use and Risk Factor Control in the United States.Journal of the American Heart Association · 2024Article
- Risk-enhancing factors and social determinants of health in risk assessment for atherosclerotic cardiovascular disease.PloS one · 2024Article
- The Pink Tax: Sex and Gender Disparities in Peripheral Artery Disease.US cardiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundStatins may be underutilized in certain vulnerable populations, but the effect of cumulative vulnerabilities within 1 individual is not well described. We sought to determine the likelihood of receiving statins with an increasing number of vulnerabilities in an individual, after controlling for factors known to influence health services utilization. METHODS AND
resultsWe identified 18 216 participants from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) study who had a statin indication or who were taking statins, as verified by pill bottle review. Statin use was assessed with respect to 5 major vulnerability domains alone and in combination: older age, black race, female sex, high area-level poverty, and lack of health insurance. The study included 5286 white men, 4180 black men, 2791 white women, and 4194 black women; 5.6% of the sample had no vulnerabilities, 20.6% had 1 vulnerability, 29.2% had 2 vulnerabilities, 27.3% had 3 vulnerabilities, and 17.3% had 4 or 5 vulnerabilities. All race-sex groups were less likely than white men to use statins; prevalence of use was 0.80 in black women with reference to white men (
conclusionsParticipants with more simultaneously occurring vulnerabilities experienced the greatest disparities in statin use. Black women and those without health insurance were at particularly high risk of underutilization.
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Registered trials
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