Evidence map›Paper›PMID 28847849›Full record

ArticleInfection and immunity2017

Otitis Media and Nasopharyngeal Colonization in

Dominik Deniffel, Brian Nuyen, Kwang Pak, Keigo Suzukawa, Jun Hung, Arwa Kurabi, Stephen I Wasserman, Allen F Ryan

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection and immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Dysregulation of immune response in otitis media.Expert reviews in molecular medicine · 2021
    Pooled it
  2. Review
  3. Article
  4. Article
  5. Leukotriene B4 Is a Major Determinant of Leukocyte Recruitment During Otitis Media.Frontiers in cellular and infection microbiology · 2021
    Article
  6. Panel 8: Vaccines and immunology.International journal of pediatric otorhinolaryngology · 2020
    Review
  7. Panel 3: Genomics, precision medicine and targeted therapies.International journal of pediatric otorhinolaryngology · 2020
    Review
  8. Panel 7 - Pathogenesis of otitis media - a review of the literature between 2015 and 2019.International journal of pediatric otorhinolaryngology · 2020
    Review
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Dominik DeniffelDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Brian NuyenDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Kwang PakDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Keigo SuzukawaDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Jun HungDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Arwa KurabiDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA.
Stephen I WassermanMedicine/Rheumatology, Allergy and Immunology, University of California, San Diego, La Jolla, California, USA.
Allen F RyanDepartment of Surgery/Otolaryngology, University of California, San Diego, La Jolla, California, USA afryan@ucsd.edu.
University of California, San Diego · USVA San Diego Healthcare System · USOrtenau Klinikum · DE

Funding

Middle ear responses in Otitis MediaR01DC000129 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 1989 to 2021
$6.8M
Innovative therapy for diseases of the middle earR01DC012595 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI RYAN, ALLEN F. · 2012 to 2023
$3.3M
Mechanisms of Persistence and Recovery in Otitis MediaR01DC006279 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WASSERMAN, STEPHEN I · 2003 to 2014
$3.1M
Establishment of an animal model of human-specific responses to middle ear infection.R03DC014801 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KURABI, ARWA · 2016 to 2018
$465k
Basic Mechanisms on Hearing Loss of Cochlear OriginI01BX001205 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI RYAN, ALLEN F. · 2013 to 2024
–
A Biological Interface for Auditory Rehabilitation with a Cochlear ImplantI01RX000977 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI RYAN, ALLEN F. · 2014 to 2016
–
BLRD VA I01 BX001205NIDCD NIH HHS R01 DC000129NIDCD NIH HHS R01 DC006279NIDCD NIH HHS R01 DC012595NIDCD NIH HHS R03 DC014801RRD VA I01 RX000977
6 · The paper itself

Abstract

We previously found CC chemokine ligand 3 (CCL3) to be a potent effector of inflammation during otitis media (OM): exogenous CCL3 rescues the OM phenotype of tumor necrosis factor-deficient mice and the function of macrophages deficient in several innate immune molecules. To further delineate the role of CCL3 in OM, we evaluated middle ear (ME) responses of

Indexed as

AnimalsBacterial LoadCell MovementChemokine CCL2Chemokine CCL3Chemokine CCL7Disease Models, AnimalEar, MiddleGene Expression RegulationHaemophilus InfectionsHaemophilus influenzaeHost-Pathogen InteractionsLeukocytesMacrophagesMiceMice, KnockoutCcl12 protein, mouseCcl2 protein, mouseCcl3 protein, mouseCcl7 protein, mouseChemokine CCL2Chemokine CCL3Chemokine CCL7Monocyte Chemoattractant Proteinschemokinesinnate immunitymucosal floranasopharyngeal culturenontypeable Haemophilus influenzaeotitis media

Identifiers

PMID28847849
PMCPMC5649018
OpenAlexW2745577881

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.