Evidence map›Paper›PMID 28847811›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2017

Restoration of Motor Defects Caused by Loss of

Kayly M Lembke, Charles Scudder, David B Morton

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Knockdown of themicroPublication biology · 2024
    Article
  3. Amyotrophic Lateral Sclerosis Genes inInternational journal of molecular sciences · 2021
    Review
  4. Article
  5. Exploring the Interaction ofJournal of experimental neuroscience · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kayly M LembkeProgram in Molecular and Cellular Biosciences, Department of Physiology and Pharmacology, and.ORCID 0000-0002-8575-1940
Charles ScudderDepartment of Integrative Biosciences, Oregon Health & Sciences University, Portland, Oregon 97239.ORCID 0000-0002-6970-305X
David B MortonDepartment of Integrative Biosciences, Oregon Health & Sciences University, Portland, Oregon 97239 mortonda@ohsu.edu.ORCID 0000-0002-1320-653X
Oregon Health & Science University · US

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
Using Drosophila as a model to understand TDP-43 function in ALSR21NS071186 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI MORTON, DAVID B · 2011 to 2012
$410k
NIH HHS P40 OD018537NINDS NIH HHS R21 NS071186
6 · The paper itself

Abstract

Defects in the RNA-binding protein, TDP-43, are known to cause a variety of neurodegenerative diseases, including amyotrophic lateral sclerosis and frontotemporal lobar dementia. A variety of experimental systems have shown that neurons are sensitive to TDP-43 expression levels, yet the specific functional defects resulting from TDP-43 dysregulation have not been well described. Using the

Indexed as

AnimalsBrainCalcium ChannelsDNA-Binding ProteinsDrosophilaDrosophila ProteinsEvoked Potentials, MotorLocomotionNeuromuscular JunctionNeuronscac protein, DrosophilaCalcium ChannelsDNA-Binding ProteinsDrosophila ProteinsTBPH protein, Drosophilaamyotrophic lateral sclerosiscalcium channelfrontotemporal lobar dementiamotor programTDP-43

Identifiers

PMID28847811
PMCPMC5618265
OpenAlexW2747487116

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.