ArticleAcademic radiology2017
Increased Epicardial Fat Volume Is Independently Associated with the Presence and Severity of Systemic Sclerosis.
Article in Academic radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Associations between anthropometric and body composition indices with subclinical arterial damage in chronic inflammatory diseases.International journal of obesity (2005) · 2026Article
- The relationship between epicardial adipose tissue and mortality in systemic sclerosis patients: 10-year follow-up results.Frontiers in cardiovascular medicine · 2026Article
- Epicardial adipose tissue provides incremental value in predicting major adverse cardiac events in systemic sclerosis patients without pulmonary arterial hypertension beyond traditional risk factors.Quantitative imaging in medicine and surgery · 2025Article
- Right atrioventricular groove epicardial fat tissue thickness is associated with right ventricular dysfunction in patients with acute pulmonary embolism.The international journal of cardiovascular imaging · 2025Article
- Article
- Prognostic Value of Epicardial Adipose Tissue in Heart Failure With Mid-Range and Preserved Ejection Fraction: A Multicenter Study.Journal of the American Heart Association · 2024Article
- Epicardial adipose tissue in patients with systemic sclerosis.European heart journal. Imaging methods and practice · 2023Article
- Perivascular adipose tissue in autoimmune rheumatic diseases.Pharmacological research · 2022Review
- Epicardial adipose tissue is associated with extent of pneumonia and adverse outcomes in patients with COVID-19.Metabolism: clinical and experimental · 2021Article
- Characterization of the inflammatory-metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution and potential treatment of the disease.European journal of heart failure · 2020Review
- Progress in Understanding, Diagnosing, and Managing Cardiac Complications of Systemic Sclerosis.Current rheumatology reports · 2019Review
- Epicardial adipose tissue thickness in systemic sclerosis patients without overt cardiac disease.Rheumatology international · 2019Article
- Water-fat magnetic resonance imaging quantifies relative proportions of brown and white adipose tissues:Journal of medical imaging (Bellingham, Wash.) · 2018Article
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Authors and funding
6 authors.
Funding
Abstract
RATIONALE AND
objectivesThe study aimed to determine if intrathoracic fat volumes are associated with the presence and severity of systemic sclerosis (SSc), defined by the presence of pulmonary arterial hypertension (PAH). MATERIALS AND
methodsA total of 265 patients were included in the study, 202 of whom had SSc (134 had SSc with no PAH and 68 had SSc-associated PAH) and who underwent high-resolution computed tomography, and 63 controls who underwent coronary computed tomography angiography with calcium scoring. Intrathoracic and epicardial (EFV) fat volumes were quantified by manual tracing of the mediastinum and the pericardium, the difference of which represents the extrapericardial fat volume. Associations between these three fat volumes and the presence and severity of SSc, adjusted for cardiovascular risk factors and interstitial lung disease, were evaluated by logistic regression analysis.
resultsOf the 202 patients with SSc, the mean age was 55 years (ranged from 20 to 86), and 79% (159 of 202) were women. Adjusted EFV (odds ratio [OR]: 1.065; 95% confidence interval [CI]: 1.046-1.084, P = < 0.0001), extrapericardial fat volume (OR: 1.028, 95% CI: 1.017-1.038, P = < 0.0001), and intrathoracic fat volume (OR: 1.033, 95% CI: 1.023-1.043, P = 0.001) were associated with the presence of SSc. Only EFV was associated with SSc severity (adjusted OR: 1.010, 95% CI: 1.003-1.018, P = 0.007).
conclusionIncreased epicardial fat volume is associated with the presence and severity of SSc, independent of cardiovascular risk factors and interstitial lung disease.
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