Evidence map›Paper›PMID 28846801›Full record

ArticleActa psychiatrica Scandinavica2017

Increased illness burden in women with comorbid bipolar and premenstrual dysphoric disorder: data from 1 099 women from STEP-BD study.

A Slyepchenko, B N Frey, B Lafer, A A Nierenberg, G S Sachs, R S Dias

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In one paragraph

Article in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  5. Sex Differences in Brain Disorders.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

A SlyepchenkoMiNDS Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.ORCID 0000-0003-0179-2129
B N FreyMiNDS Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada.
B LaferBipolar Disorder Research Program, Department of Psychiatry, University of São Paulo Medical School, Sao Paulo, Brazil.
A A NierenbergDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
G S SachsDepartment of Psychiatry, Harvard Medical School, Boston, MA, USA.
R S DiasBipolar Disorder Research Program, Department of Psychiatry, University of São Paulo Medical School, Sao Paulo, Brazil.
Harvard University · USSt. Joseph’s Healthcare Hamilton · CAUniversidade de São Paulo · BR

Funding

TREATMENT OF BIPOLAR DISORDER-278980001N01MH080001 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · 1998 to 2003
$5.3M
NIMH NIH HHS N01 MH080001
6 · The paper itself

Abstract

backgroundThe impact of comorbid premenstrual dysphoric disorder (PMDD) in women with bipolar disorder (BD) is largely unknown.

aimsWe compared illness characteristics and female-specific mental health problems between women with BD with and without PMDD. MATERIALS &

methodsA total of 1 099 women with BD who participated in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) were studied. Psychiatric diagnoses and illness characteristics were assessed using the Mini International Neuropsychiatric Interview. Female-specific mental health was assessed using a self-report questionnaire developed for STEP-BD. PMDD diagnosis was based on DSM-5 criteria.

resultsWomen with comorbid BD and PMDD had an earlier onset of bipolar illness (P < 0.001) and higher rates of rapid cycling (P = 0.039), and increased number of past-year hypo/manic (P = 0.003), and lifetime/past-year depressive episodes (P < 0.05). Comorbid PMDD was also associated with higher proportion of panic disorder, post-traumatic stress disorder, generalized anxiety disorder, bulimia nervosa, substance abuse, and adult attention deficit disorder (all P < 0.05). There was a closer gap between BD onset and age of menarche in women with comorbid PMDD (P = 0.003). Women with comorbid PMDD reported more severe mood symptoms during the perinatal period and while taking oral contraceptives (P < 0.001). DISCUSSION: The results from this study is consistent with research suggesting that sensitivity to endogenous hormones may impact the onset and the clinical course of BD.

conclusionsThe comorbidity between PMDD and BD is associated with worse clinical outcomes and increased illness burden.

Indexed as

ComorbidityCost of IllnessAdolescentAdultBipolar DisorderFemaleHumansMiddle AgedPremenstrual Dysphoric DisorderYoung Adultage of onsetbipolar disorderburden of illnessmenarchepremenstrual dysphoric disorder

Identifiers

PMID28846801
PMCPMC5630503
OpenAlexW2748752460

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.