ArticlePloS one2017
Role of amygdala kisspeptin in pubertal timing in female rats.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 41 citations in OpenAlex.
- Hypothalamic control of puberty: from neuronal circuits to mechanisms for its metabolic regulation.Reviews in endocrine & metabolic disorders · 2026Review
- The role of amygdala GABA neurons in controlling stress and reproduction in female mice.Nature communications · 2026Article
- The Neuroendocrine Regulation of Reproductive Behavior and Emotional Control by Kisspeptin.The Journal of clinical endocrinology and metabolism · 2025Review
- Neuronal network dynamics in the posterodorsal amygdala: shaping reproductive hormone pulsatility.Journal of the Royal Society, Interface · 2024Article
- Maternal cafeteria diet influences kisspeptin (Kiss1), kisspeptin receptor(Gpr54), and sirtuin (Sirt1) genes, hormonal and metabolic profiles, and reproductive functions in rat offspring in a sex-specific manner†.Biology of reproduction · 2023Article
- Molecular basis of normal and pathological puberty: from basic mechanisms to clinical implications.The lancet. Diabetes & endocrinology · 2023Review
- Posterodorsal Medial Amygdala Urocortin-3, GABA, and Glutamate Mediate Suppression of LH Pulsatility in Female Mice.Endocrinology · 2022Article
- Current Perspectives on Kisspeptins Role in Behaviour.Frontiers in endocrinology · 2022Review
- Role of Posterodorsal Medial Amygdala Urocortin-3 in Pubertal Timing in Female Mice.Frontiers in endocrinology · 2022Article
- Extrahypothalamic Control of Energy Balance and Its Connection with Reproduction: Roles of the Amygdala.Metabolites · 2021Review
- Urocortin3 in the Posterodorsal Medial Amygdala Mediates Stress-induced Suppression of LH Pulsatility in Female Mice.Endocrinology · 2021Article
- Chronic exposure to perfluorohexane sulfonate leads to a reproduction deficit by suppressing hypothalamic kisspeptin expression in mice.Journal of ovarian research · 2021Article
- Kisspeptin modulates gamma-aminobutyric acid levels in the human brain.Psychoneuroendocrinology · 2021Article
- Peripheral action of kisspeptin at reproductive tissues-role in ovarian function and embryo implantation and relevance to assisted reproductive technology in livestock: a review.Biology of reproduction · 2020Review
- Pubertal development mediates the association between family environment and brain structure and function in childhood.Development and psychopathology · 2020Article
- Novel insights into the metabolic action of Kiss1 neurons.Endocrine connections · 2020Review
- Optogenetic stimulation of kisspeptin neurones within the posterodorsal medial amygdala increases luteinising hormone pulse frequency in female mice.Journal of neuroendocrinology · 2020Article
- KISS1 Suppresses Apoptosis and Stimulates the Synthesis of E2 in Porcine Ovarian Granulosa Cells.Animals : an open access journal from MDPI · 2019Article
- Article
- Genome-wide DNA methylation analysis of pituitaries during the initiation of puberty in gilts.PloS one · 2019Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
To investigate the mechanism by which maternal obesity disrupts reproductive function in offspring, we examined Kiss1 expression in the hypothalamic arcuate (ARC) and anteroventral periventricular (AVPV) nuclei, and posterodorsal medial amygdala (MePD) of pre-pubertal and young adult offspring. Sprague-Dawley rats were fed either a standard or energy-dense diet for six weeks prior to mating and throughout pregnancy and lactation. Male and female offspring were weaned onto normal diet on postnatal day (pnd) 21. Brains were collected on pnd 30 or 100 for qRT-PCR to determine Kiss1 mRNA levels. Maternal obesity increased Kiss1 mRNA expression in the MePD of pre-pubertal male and female offspring, whereas Kiss1 expression was not affected in the ARC or AVPV at this age. Maternal obesity reduced Kiss1 expression in all three brain regions of 3 month old female offspring, but only in MePD of males. The role of MePD kisspeptin on puberty, estrous cyclicity and preovulatory LH surges was assessed directly in a separate group of post-weanling and young adult female rats exposed to a normal diet throughout their life course. Bilateral intra-MePD cannulae connected to osmotic mini-pumps for delivery of kisspeptin receptor antagonist (Peptide 234 for 14 days) were chronically implanted on pnd 21 or 100. Antagonism of MePD kisspeptin delayed puberty onset, disrupted estrous cyclicity and reduced the incidence of LH surges. These data show that the MePD plays a key role in pubertal timing and ovulation and that maternal obesity may act via amygdala kisspeptin signaling to influence reproductive function in the offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.