SynthesisPloS one2017
Constraint-induced aphasia therapy in post-stroke aphasia rehabilitation: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Group rehabilitation for adults with acquired neurological disorders: A systematic review of mono- and interdisciplinary interventions in physical and speech-language therapy.PM & R : the journal of injury, function, and rehabilitation · 2026Pooled it
- Speech therapy for poststroke aphasia: a network meta-analysis of randomized controlled trials.PeerJ · 2026Pooled it
- Effect of mobile application types on stroke rehabilitation: a systematic review.Journal of neuroengineering and rehabilitation · 2023Pooled it
- Results of the COMPARE trial of Constraint-induced or Multimodality Aphasia Therapy compared with usual care in chronic post-stroke aphasia.Journal of neurology, neurosurgery, and psychiatry · 2022Trial
- Aphasia Rehabilitation in India: Current Practices and Future Directions.Healthcare (Basel, Switzerland) · 2026Article
- Current status of Tele-speech language therapy by type and support for patients with post-stroke aphasia: A scoping review.PloS one · 2025Article
- The Neuropsychological Assessment of Unilateral Spatial Neglect Through Computerized and Virtual Reality Tools: A Scoping Review.Neuropsychology review · 2024Article
- Predicting the functional outcome of intensive inpatient rehabilitation after stroke: results from the RIPS Study.European journal of physical and rehabilitation medicine · 2024Observational
- Treatment of post-stroke aphasia: A narrative review for stroke neurologists.International journal of stroke : official journal of the International Stroke Society · 2021Review
- Novel Advances to Post-Stroke Aphasia Pharmacology and Rehabilitation.Journal of clinical medicine · 2021Review
- Acquired Brain Injury in Adults: A Review of Pathophysiology, Recovery, and Rehabilitation.Perspectives of the ASHA special interest groups · 2021Article
- Current Approaches to the Treatment of Post-Stroke Aphasia.Journal of stroke · 2021Review
- The sensitivity of event-related potentials/fields to logopedic interventions in patients with stroke-related aphasia.Acta neurologica Belgica · 2020Review
- Constraint-induced aphasia therapy for patients with aphasia: A systematic review.International journal of nursing sciences · 2020Review
- [Review on the improvements in communication skills among aphasic patients through the use of portable technology.]Revista espanola de salud publica · 2020Review
- Constrained-Induced Dysarthria Therapy: Case Report.Annals of rehabilitation medicine · 2019Article
- Principles of Neurorehabilitation After Stroke Based on Motor Learning and Brain Plasticity Mechanisms.Frontiers in systems neuroscience · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConstraint-induced aphasia therapy (CIAT) has been widely used in post-stroke aphasia rehabilitation. An increasing number of clinical controlled trials have investigated the efficacy of the CIAT for the post-stroke aphasia. PURPOSE: To systematically review the randomized controlled trials (RCTs) concerning the effect of the CIAT in post-stroke patients with aphasia, and to identify the useful components of CIAT in post-stroke aphasia rehabilitation.
methodsA computerized database search was performed through five databases (Pubmed, EMbase, Medline, ScienceDirect and Cochrane library). Cochrane handbook domains were used to evaluate the methodological quality of the included RCTs.
resultsEight RCTs qualified in the inclusion criteria. Inconsistent results were found in comparing the CIAT with conventional therapies without any component from the CIAT based on the results of three RCTs. Five RCTs showed that the CIAT performed equally well as other intensive aphasia therapies, in terms of improving language performance. One RCT showed that therapies embedded with social interaction were likely to enhance the efficacy of the CIAT.
conclusionCIAT may be useful for improving chronic post-stroke aphasia, however, limited evidence to support its superiority to other aphasia therapies. Massed practice is likely to be a useful component of CIAT, while the role of "constraint" is needed to be further explored. CIAT embedded with social interaction may gain more benefits.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.