ArticlePloS one2017
Aging effects on airflow dynamics and lung function in human bronchioles.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
- Human lungs fluid mechanics: an overview of current modelling techniques.The European physical journal. E, Soft matter · 2026Review
- Assessment of respiratory function status among commercial motorcycle drivers in Sawla town, southern Ethiopia: comparative cross-sectional study.Scientific reports · 2026Article
- Respiratory Depression in Non-Operating Room Anesthesia: An Overview.Journal of clinical medicine · 2025Review
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- The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung.Aging and disease · 2024Article
- The evidence does not support long-term oxygenation as a functional explanation for the evolution of yawning.Sleep & breathing = Schlaf & Atmung · 2023Article
- Inspiratory pressure waveform influences time to failure, respiratory muscle fatigue, and metabolism during resistive breathing.Physiological reports · 2023Article
- Prediction of respiratory complications by quantifying lung contusion volume using chest computed tomography in patients with chest trauma.Scientific reports · 2023Article
- Tuberculosis and COVID-19 in the elderly: factors driving a higher burden of disease.Frontiers in immunology · 2023Review
- Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing.Ageing research reviews · 2022Review
- Mathematical modeling of ventilator-induced lung inflammation.Journal of theoretical biology · 2021Article
- How severe acute respiratory syndrome coronavirus-2 aerosol propagates through the age-specific upper airways.Physics of fluids (Woodbury, N.Y. : 1994) · 2021Article
- Polydisperse Aerosol Transport and Deposition in Upper Airways of Age-Specific Lung.International journal of environmental research and public health · 2021Article
- Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population.BMC pulmonary medicine · 2020Article
- Airflow and Particle Transport Prediction through Stenosis Airways.International journal of environmental research and public health · 2020Article
- A Review of Respiratory Anatomical Development, Air Flow Characterization and Particle Deposition.International journal of environmental research and public health · 2020Review
- The Impact of Aging in Acute Respiratory Distress Syndrome: A Clinical and Mechanistic Overview.Frontiers in medicine · 2020Review
- A review of inflammatory mechanism in airway diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2019Review
- Article
- Evaluation of Ventilation-Induced Lung Inflammation Through Multi-Scale Simulations.IEEE journal of translational engineering in health and medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND AND
objectiveThe mortality rate for patients requiring mechanical ventilation is about 35% and this rate increases to about 53% for the elderly. In general, with increasing age, the dynamic lung function and respiratory mechanics are compromised, and several experiments are being conducted to estimate these changes and understand the underlying mechanisms to better treat elderly patients. MATERIALS AND
methodsHuman tracheobronchial (G1 ~ G9), bronchioles (G10 ~ G22) and alveolar sacs (G23) geometric models were developed based on reported anatomical dimensions for a 50 and an 80-year-old subject. The aged model was developed by altering the geometry and material properties of the model developed for the 50-year-old. Computational simulations using coupled fluid-solid analysis were performed for geometric models of bronchioles and alveolar sacs under mechanical ventilation to estimate the airflow and lung function characteristics.
findingsThe airway mechanical characteristics decreased with aging, specifically a 38% pressure drop was observed for the 80-year-old as compared to the 50-year-old. The shear stress on airway walls increased with aging and the highest shear stress was observed in the 80-year-old during inhalation. A 50% increase in peak strain was observed for the 80-year-old as compared to the 50-year-old during exhalation. The simulation results indicate that there is a 41% increase in lung compliance and a 35%-50% change in airway mechanical characteristics for the 80-year-old in comparison to the 50-year-old. Overall, the airway mechanical characteristics as well as lung function are compromised due to aging.
conclusionOur study demonstrates and quantifies the effects of aging on the airflow dynamics and lung capacity. These changes in the aging lung are important considerations for mechanical ventilation parameters in elderly patients. Realistic geometry and material properties need to be included in the computational models in future studies.
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