Evidence map›Paper›PMID 28846659›Full record

ReviewMarine drugs2017

Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.

Alka Choudhary, Lynn M Naughton, Itxaso Montánchez, Alan D W Dobson, Dilip K Rai

Abstract readReview
In one paragraph

Review in Marine drugs, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed.

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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Alka ChoudharyDepartment of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, Ireland. alka.choudhary@teagasc.ie.
Lynn M NaughtonSchool of Microbiology, University College Cork, Western Road, Cork City T12 YN60, Ireland. lynn.naughton@ucc.ie.
Itxaso MontánchezDepartment of Immunology, Microbiology and Parasitology, Faculty of Science, University of the Basque Country, (UPV/EHU), 48940 Leioa, Spain. itxaso.montanchez@ehu.eus.
Alan D W DobsonSchool of Microbiology, University College Cork, Western Road, Cork City T12 YN60, Ireland. a.dobson@ucc.ie.
Dilip K RaiDepartment of Food Biosciences, Teagasc Food Research Centre Ashtown, Dublin D15 KN3K, Ireland. dilip.rai@teagasc.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012-2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.

Indexed as

AlkaloidsAnti-Infective AgentsBiological ProductsHumansMarine BiologyMolecular StructurePolyketidesTerpenesAlkaloidsAnti-Infective AgentsBiological ProductsPolyketidesTerpenesantibacterialantifungalantimicrobialgenome miningmarine natural products (MNPs)secondary metabolites

Identifiers

PMID28846659
PMCPMC5618411

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.