Trial reportShock (Augusta, Ga.)2018
Pulmonary Mechanics and Mortality in Mechanically Ventilated Patients Without Acute Respiratory Distress Syndrome: A Cohort Study.
Trial report in Shock (Augusta, Ga.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Association Between Mechanical Power and Mortality in Critically Ill Patients Receiving Invasive Mechanical Ventilation: A Systematic Review and Meta-Analysis.Critical care medicine · 2026Pooled it
- Protective mechanical ventilation controlled by the real-time mechanical power measurement.Journal of clinical monitoring and computing · 2026Trial
- Association between tidal volume and mortality in patients without acute respiratory distress syndrome: A systematic review and meta-analysis.Biomedical reports · 2026Article
- Ventilator-Associated Lung Injury: Pathophysiology, Prevention, and Emerging Therapeutic Strategies.International journal of molecular sciences · 2025Review
- Observational
- Observational
- Mechanical Power Is Associated With Mortality in Pressure-Controlled Ventilated Patients: A Dutch, Single-Center Cohort Study.Critical care explorations · 2024Article
- Impact of mechanical power on ICU mortality in ventilated critically ill patients: a retrospective study with continuous real-life data.European journal of medical research · 2024Observational
- Ventilatory pressure parameters impact the association between acute gastrointestinal injury and all-cause mortality in mechanically ventilated patients.Scientific reports · 2024Observational
- Mechanical Power of Ventilation: From Computer to Clinical Implications.Respiratory care · 2023Review
- The Impact of Mechanical Energy Assessment on Mechanical Ventilation: A Comprehensive Review and Practical Application.Medical science monitor : international medical journal of experimental and clinical research · 2023Review
- Effects of obesity, pneumoperitoneum, and body position on mechanical power of intraoperative ventilation: an observational study.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Observational
- Ventilation during Lung Resection and Critical Care: Comparative Clinical Outcomes.Anesthesiology · 2022Article
- Translational Role of Rodent Models to Study Ventilator-Induced Lung Injury.Translational perioperative and pain medicine · 2021Article
- Mechanical Power: A New Concept in Mechanical Ventilation.The American journal of the medical sciences · 2021Review
- The effect of driving pressures in COVID-19 ARDS: Lower may still be better as in classic ARDS.Respiratory investigation · 2021Article
- Implementation of an ED-based bundled mechanical ventilation protocol improves adherence to lung-protective ventilation.The American journal of emergency medicine · 2021Observational
- Impact of Height Estimation on Tidal Volume Calculation for Protective Ventilation-A Prospective Observational Study.Critical care explorations · 2021Article
- [Reinterpreting the ventilator-induced lung injury from the prospective of mechanical power].Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns · 2021Article
- The relationship of tidal volume and driving pressure with mortality in hypoxic patients receiving mechanical ventilation.PloS one · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
backgroundDriving pressure has been proposed as a major determinant of outcome in patients with acute respiratory distress syndrome (ARDS), but there is little data examining the association between pulmonary mechanics, including driving pressure, and outcomes in mechanically ventilated patients without ARDS.
methodsSecondary analysis from 1,705 mechanically ventilated patients enrolled in a clinical study that examined outcomes associated with the use of early lung-protective mechanical ventilation. The primary outcome was mortality and the secondary outcome was the incidence of ARDS. Multivariable models were constructed to: define the association between pulmonary mechanics (driving pressure, plateau pressure, and compliance) and mortality; and evaluate if driving pressure contributed information beyond that provided by other pulmonary mechanics.
resultsThe mortality rate for the entire cohort was 26.0%. Compared with survivors, non-survivors had significantly higher driving pressure [15.9 (5.4) vs. 14.9 (4.4), P = 0.005] and plateau pressure [21.4 (5.7) vs. 20.4 (4.6), P = 0.001]. Driving pressure was independently associated with mortality [adjusted OR, 1.04 (1.01-1.07)]. Models related to plateau pressure also revealed an independent association with mortality, with similar effect size and interval estimates as driving pressure. There were 152 patients who progressed to ARDS (8.9%). Along with driving pressure and plateau pressure, mechanical power [adjusted OR, 1.03 (1.00-1.06)] was also independently associated with ARDS development.
conclusionsIn mechanically ventilated patients, driving pressure and plateau pressure are risk factors for mortality and ARDS, and provide similar information. Mechanical power is also a risk factor for ARDS.
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