Evidence map›Paper›PMID 28846469›Full record

Trial reportJournal of dental research2018

Randomized Clinical Trial of 12% and 38% Silver Diamine Fluoride Treatment.

M H T Fung, D Duangthip, M C M Wong, E C M Lo, C H Chu

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of dental research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 115 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 10 pooled it
13.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02385474 phase3completednot on this map

Effectiveness of Silver Diamine Fluoride in Arresting Dental Caries in Preschool Children: a Randomized Clinical Trial With Different Periodicity and Concentration.

TypeinterventionalSponsorThe University of Hong KongRan2013Enrolled888ConditionsEarly Childhood CariesArms12% SDF, 38% SDF
NCT05872542 phase4unknown statusnot on this mapstarted 2023, after this paper: background citation

Clinical Effectiveness of Silver Diamine Fluoride on Arresting Caries Lesions in Children

TypeinterventionalSponsorUmm Al-Qura UniversityRan2023 to 2024Enrolled60ConditionsDental Caries in ChildrenArmsSilver Diamine Fluoride (SDF), Glass Ionomer Restoration (GI), Sodium fluoride varnish with nano-sliver particles (NaF-AgNP)
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 10 syntheses or guidelines pooled it, 245 citations in OpenAlex.

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  11. Comparative evaluation of saturated and 10% potassium iodide in reducing silver diamine fluoride staining under RMGIC restorations in primary teeth.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

M H T Fung1 Faculty of Dentistry, The University of Hong Kong, Hong Kong.
D Duangthip1 Faculty of Dentistry, The University of Hong Kong, Hong Kong.
M C M Wong1 Faculty of Dentistry, The University of Hong Kong, Hong Kong.
E C M Lo1 Faculty of Dentistry, The University of Hong Kong, Hong Kong.
C H Chu1 Faculty of Dentistry, The University of Hong Kong, Hong Kong.
University of Hong Kong · HK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This 30-mo randomized clinical trial compared the effectiveness of 2 concentrations (12% or 38%) of silver diamine fluoride (SDF) and 2 periodicity of application (once or twice a year) in arresting cavitated dentin caries in primary teeth. Children aged 3 to 4 y who had at least 1 active cavitated caries lesion were enrolled and randomly allocated into 4 groups for intervention. Group 1 had 12% SDF applied annually (every 12 mo), group 2 had 12% SDF applied semiannually (every 6 mo), group 3 had 38% SDF applied annually, and group 4 had 38% SDF applied semiannually. Clinical examinations were performed semiannually in kindergarten by a single examiner to investigate whether the SDF-treated caries became arrested. A total of 888 children with 4,220 decayed tooth surfaces received SDF application at baseline, and 799 (90.0%) children with 3,790 surfaces (89.8%) were evaluated at the 30-mo examination. The caries arrest rates were 55.2%, 58.6%, 66.9%, and 75.7% for groups 1, 2, 3, and 4, respectively ( P < 0.001). Caries treated with 38% SDF had a higher chance of becoming arrested than those treated with 12% SDF (odds ratio [OR], 1.98; 95% confidence interval [CI], 1.51-2.60, P < 0.001). The interaction between frequency of SDF application and visible plaque index (VPI) score was significant ( P = 0.017). Among those children who received annual SDF application, children with a higher VPI score had a lower chance to have their caries become arrested (OR, 0.59, 95% CI, 0.49-0.72). In conclusion, SDF at a concentration of 38% is more effective than that of 12% in arresting active caries in primary teeth. For children with poor oral hygiene, caries arrest rate of SDF treatment can be increased by increasing the frequency of application from annually to semiannually ( ClinicalTrials.gov NCT02385474).

Indexed as

Cariostatic AgentsChild, PreschoolDental CariesFemaleFluorides, TopicalHong KongHumansMaleQuaternary Ammonium CompoundsSilver CompoundsTooth, DeciduousTreatment OutcomeCariostatic AgentsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluoridechildclinical studies/trialsdental cariesdentinprimary teethsilver compounds

Identifiers

PMID28846469
PMCPMC6429575
OpenAlexW2750360976

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.