Evidence map›Paper›PMID 28846437›Full record

ArticleAmerican journal of respiratory cell and molecular biology2018

Oxygen Administration Improves Survival but Worsens Cardiopulmonary Functions in Chlorine-exposed Rats.

Obiefuna C Okponyia, Matthew D McGraw, Marilyn M Dysart, Rhonda B Garlick, Jacqueline S Rioux, Angela L Murphy, Gates B Roe, Carl W White, Livia A Veress

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Update in Critical Care and Acute Respiratory Distress Syndrome 2018.American journal of respiratory and critical care medicine · 2019
    Article
  4. Bromine inhalation mimics ischemia-reperfusion cardiomyocyte injury and calpain activation in rats.American journal of physiology. Heart and circulatory physiology · 2019
    Article
  5. Chlorine Countermeasures: Supplemental Oxygen Equals Supplemental Lung Injury?American journal of respiratory cell and molecular biology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Obiefuna C OkponyiaDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Matthew D McGrawDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Marilyn M DysartDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Rhonda B GarlickDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Jacqueline S RiouxDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Angela L MurphyDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Gates B RoeDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Carl W WhiteDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
Livia A VeressDepartment of Pediatrics, University of Colorado Denver, Aurora, Colorado.
University of Colorado Denver · USThe Medical Center of Aurora · US

Funding

Photonics Monitoring and Modeling CoreU54ES027698 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI WHITE, CARL W · 2016 to 2021
$16.7M
ACADEMIC TRAINING PROGRAM IN PEDIATRIC PULMONARY DISEASET32HL007670 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ABMAN, STEVEN HERBERT · 1988 to 2019
$5.9M
NHLBI NIH HHS T32 HL007670NIEHS NIH HHS U54 ES027698
6 · The paper itself

Abstract

Chlorine is a highly reactive gas that can cause significant injury when inhaled. Unfortunately, its use as a chemical weapon has increased in recent years. Massive chlorine inhalation can cause death within 4 hours of exposure. Survivors usually require hospitalization after massive exposure. No countermeasures are available for massive chlorine exposure and supportive-care measures lack controlled trials. In this work, adult rats were exposed to chlorine gas (LD

Indexed as

Respiratory InsufficiencyAcute DiseaseAnimalsCardiac OutputChemical Warfare AgentsChlorineHypercapniaMaleOxygenRatsRats, Sprague-DawleyChemical Warfare AgentsChlorineOxygenchlorine gashypoxemiaoxygenrespiratory distressseizure

Identifiers

PMID28846437
PMCPMC5941308
OpenAlexW2748524955

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.