ArticleThe Lancet. Infectious diseases2017
Symptomatic dengue infection during pregnancy and the risk of stillbirth in Brazil, 2006-12: a matched case-control study.
Article in The Lancet. Infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Burden of Dengue in Pregnant Individuals: A Systematic Literature Review.The American journal of tropical medicine and hygiene · 2026Pooled it
- A Systematic Review and Meta-Analysis of Maternal Dengue Infection and Adverse Pregnancy Outcomes.Cureus · 2025Review
- Severe neonatal dengue with confirmed vertical transmission of DENV-3: A fatal case from Honduras.IDCases · 2025Article
- A nationwide longitudinal investigation on the role of prenatal exposure to infectious diseases on the onset of chronic conditions in children and adolescents in Brazil.Wellcome open research · 2024Article
- Arthropod-Borne Flaviviruses in Pregnancy.Microorganisms · 2023Review
- Adverse pregnancy outcomes during the COVID-19 lockdown. A descriptive study.BMC pregnancy and childbirth · 2021Article
- Vertical transmission of Zika virus and its outcomes: a Bayesian synthesis of prospective studies.The Lancet. Infectious diseases · 2021Article
- CIDACS-RL: a novel indexing search and scoring-based record linkage system for huge datasets with high accuracy and scalability.BMC medical informatics and decision making · 2020Article
- Q fever seroprevalence in parturient women: the EQRUN cross-sectional study on Reunion Island.BMC infectious diseases · 2020Article
- Dengue and malaria infections in pregnancy : Maternal, fetal and neonatal outcomes at a tertiary care hospital.Wiener klinische Wochenschrift · 2020Article
- Nested exposure case-control sampling: a sampling scheme to analyze rare time-dependent exposures.Lifetime data analysis · 2020Article
- Dengue virus infection and pregnancy outcomes during the 2017 outbreak in Ouagadougou, Burkina Faso: A retrospective cohort study.PloS one · 2020Article
- The Centre for Data and Knowledge Integration for Health (CIDACS): Linking Health and Social Data in Brazil.International journal of population data science · 2019Article
- Dengue during pregnancy and live birth outcomes: a cohort of linked data from Brazil.BMJ open · 2019Article
- Article
- Symptomatic Dengue during Pregnancy and Congenital Neurologic Malformations.Emerging infectious diseases · 2018Article
- The prediction of fetal death with a simple maternal blood test at 20-24 weeks: a role for angiogenic index-1 (PlGF/sVEGFR-1 ratio).American journal of obstetrics and gynecology · 2017Article
- Evaluation of record linkage of two large administrative databases in a middle income country: stillbirths and notifications of dengue during pregnancy in Brazil.BMC medical informatics and decision making · 2017Article
- Vector-borne diseases in pregnancy.Therapeutic advances in infectious diseaseReview
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Authors and funding
7 authors at 3 institutions in 2 countries.
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Abstract
backgroundMaternal infections during pregnancy can increase the risk of fetal death. Dengue infection is common, but little is known about its role in fetal mortality. We aimed to investigate the association between symptomatic dengue infection during pregnancy and fetal death.
methodsWe did a nested case-control study using obstetrician-collected data from the Brazilian livebirth information system (SINASC), the mortality information system (SIM), and the national reportable disease information system (SINAN). We identified all pregnancies ending in stillbirth and a random sample of livebirths between Jan 1, 2006, and Dec 31, 2012. We did linkage to determine which mothers were diagnosed with dengue infection during pregnancy. By use of stillbirths as cases and a sample of matched livebirths as a control, we calculated matched odds ratios (mORs) using conditional logistic regression adjusted for maternal age and education.
findings275 (0·2%) of 162 188 women who had stillbirths and 1507 (0·1%) of 1 586 105 women who had livebirths were diagnosed with dengue infection during pregnancy. Symptomatic dengue infection during pregnancy almost doubled the odds of fetal death (mOR 1·9, 95% CI 1·6-2·2). The increase in risk was similar when analyses were restricted to laboratory-confirmed cases of dengue infection (1·8, 1·4-2·4). Severe dengue infection increased the risk of fetal death by about five times (4·9, 2·3-10·2).
interpretationSymptomatic dengue infection during pregnancy is associated with an increased risk of fetal death. We recommend further epidemiological and biological studies of the association between dengue and poor birth outcomes to measure the burden of subclinical infections and elucidate pathological mechanisms.
fundingBrazilian National Council for Scientific and Technological Development, Horizon 2020.
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