ArticleIranian journal of public health2017
Efficacy of Botox versus Placebo for Treatment of Patients with Major Depression.
Article in Iranian journal of public health, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Botulinum Toxin Injections for Psychiatric Disorders: A Systematic Review of the Clinical Trial Landscape.Toxins · 2024Pooled it
- Efficacy of onabotulinumtoxinA in the treatment of unipolar major depression: Systematic review, meta-analysis and meta-regression analyses of double-blind randomised controlled trials.Journal of psychopharmacology (Oxford, England) · 2021Pooled it
- Efficacy and Safety of Botulinum Toxin vs. Placebo in Depression: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Frontiers in psychiatry · 2020Pooled it
- OnabotulinumtoxinA in Resistant Depression: A Randomized Trial Comparing Two Facial Injection Sites (OnaDEP Study).Depression and anxiety · 2024Trial
- Neuronal effects of glabellar botulinum toxin injections using a valenced inhibition task in borderline personality disorder.Scientific reports · 2022Trial
- Botulinum Toxin: An Unconventional Tool for the Treatment of Depression?Brain sciences · 2025Review
- Efficacy of Facial Botulinum Toxin A Injections in Alleviating Neuropsychiatric Symptoms in Parkinson's Disease Patients: An Open-Label, Nonrandomized Controlled Trial.Brain and behavior · 2025Article
- Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.Acta neurologica Belgica · 2025Article
- The Face of Emotion: Botulinum Toxin, Emotional Anatomy, and Mood Modulation.Journal of cosmetic dermatology · 2025Review
- Effects of glabellar botulinum toxin injections on resting-state functional connectivity in borderline personality disorder.European archives of psychiatry and clinical neuroscience · 2024Article
- Botulinum neurotoxins: Future innovations.Medicine · 2023Article
- Botox (onabotulinumtoxinA) mechanism of action.Medicine · 2023Article
- Review
- Botulinum Toxin Therapy for Psychiatric Disorders in Clinical Practice: A Retrospective Case Study.Toxins · 2023Article
- Review
- Neurotoxins Acting at Synaptic Sites: A Brief Review on Mechanisms and Clinical Applications.Toxins · 2022Review
- Botulinum Toxin in Facial Aesthetics Affects the Emotion Process: A Meta-analysis of Randomized Controlled Trials.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2022Review
- Treatment of Depression with Botulinum Toxin.Toxins · 2022Review
- The Use of Botulinum Toxin for Treatment of Depression.Handbook of experimental pharmacology · 2021Article
- Postmarketing safety surveillance data reveals antidepressant effects of botulinum toxin across various indications and injection sites.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTreatment of major depression is crucial to decrease the burden of disease. Hence, in this study, the efficacy of Botox was compared with placebo for treatment of patients with major depression.
methodsIn this randomized clinical trial, 28 consecutive patients with major depression were enrolled. The patients were randomly assigned to receive either Botox or placebo and the scores of Beck Depression Inventory were determined and compared at baseline and after two and six weeks in the groups and between the groups. In addition, the drug adverse effects were compared between groups. This study had been registered in TCTR with TCTR20170409001 code.
resultsThere was a statistically significant difference two group for 6
conclusionFinally, Botox is effective for treatment of patients with major depression and it has a high safety.
Indexed as
Identifiers
28845410PMC5563881W2743778946What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.