Evidence map›Paper›PMID 28845162›Full record

ArticleStem cells international2017

Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms' Tumors.

Heloisa Cristina Caldas, Fernando Henrique Lojudice, Cinthia Dias, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Rosa Sayoko Kawasaki-Oyama, Mari Cleide Sogayar, Christina Maeda Takiya, Mario Abbud-Filho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Advances in Clinical Research in Chronic Kidney Disease.Journal of translational internal medicine · 2021
    Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Growing a new human kidney.Kidney international · 2019
    Review
  17. Stem Cell Therapies in Kidney Diseases: Progress and Challenges.International journal of molecular sciences · 2019
    Review
  18. Review
  19. Urine-derived cells for human cell therapy.Stem cell research & therapy · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Heloisa Cristina CaldasLaboratory of Immunology and Experimental Transplantation (LITEX), Department of Medicine FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.ORCID 0000-0002-0948-9821
Fernando Henrique LojudiceNUCEL-NETCEM Cell and Molecular Therapy Center, Medical Clinics Department, School of Medicine, University of São Paulo, Sao Paulo, SP, Brazil.
Cinthia DiasLaboratory of Immunology and Experimental Transplantation (LITEX), Department of Medicine FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.
Ida Maria Maximina Fernandes-CharpiotLaboratory of Immunology and Experimental Transplantation (LITEX), Department of Medicine FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.
Maria Alice Sperto Ferreira BaptistaLaboratory of Immunology and Experimental Transplantation (LITEX), Department of Medicine FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.
Rosa Sayoko Kawasaki-OyamaGenetics and Molecular Biology Research Unit Laboratory-UPGEM, FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.
Mari Cleide SogayarNUCEL-NETCEM Cell and Molecular Therapy Center, Medical Clinics Department, School of Medicine, University of São Paulo, Sao Paulo, SP, Brazil.
Christina Maeda TakiyaLaboratório de Imunopatologia, Instituto de Biofísica Carlos Chagas Filho, Rio de Janeiro, RJ, Brazil.
Mario Abbud-FilhoLaboratory of Immunology and Experimental Transplantation (LITEX), Department of Medicine FAMERP Medical School, Sao Jose do Rio Preto, SP, Brazil.ORCID 0000-0002-5079-9813
Faculdade de Medicina de São José do Rio Preto · BRUniversidade de São Paulo · BRFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The therapeutic effect of induced pluripotent stem cells (iPSs) on the progression of chronic kidney disease (CKD) has not yet been demonstrated. In this study, we sought to assess whether treatment with iPSs retards progression of CKD when compared with bone marrow mesenchymal stem cells (BMSCs). Untreated 5/6 nephrectomized rats were compared with CKD animals receiving BMSCs or iPSs. Renal function, histology, immunohistochemistry, and gene expression were studied. Implanted iPSs were tracked by the SRY gene expression analysis. Both treatments minimized elevation in serum creatinine, significantly improved clearance, and slowed down progression of disease. The proteinuria was reduced only in the iPS group. Both treatments reduced glomerulosclerosis, iPSs decreased macrophage infiltration, and TGF-

Identifiers

PMID28845162
PMCPMC5560097
OpenAlexW2743111712

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.