ArticleActa medica Lituanic2017
Results of neuroblastoma treatment in Lithuania: a single centre experience.
Article in Acta medica Lituanic, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The impact of incomplete registration on survival rate of children with very rare tumors.Scientific reports · 2021Article
- Improvement in childhood cancer survival in Lithuania over three decades.Acta medica Lituanic · 2020Article
- Wilms tumour in children: 18 years of experience at Vilnius University Hospital Santaros Klinikos, Lithuania.Acta medica Lituanic · 2019Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundNeuroblastoma (NB) is the most common extracranial solid tumour in children. This is a very rare disease with heterogeneous biology varying from complete spontaneous regression to a highly aggressive tumour responsible for 15% of malignancy-related death in early childhood. Analyses of survival rates in Europe have shown a considerable difference between Northern/Western and Eastern European countries. Treatment results of NB in Lithuania have never been analyzed.
aimTo assess the survival rate of children with NB according to initial spread of the disease, age at diagnosis, the MYCN amplification, risk group, and treatment period. PATIENTS AND
methodsA retrospective single-centre analysis of patients' records was performed. Children diagnosed and treated for NB between 2000 and 2015 at the Centre of Paediatric Oncology and Haematology of the Children's Hospital, Affiliate of Vilnius University Hospital Santaros Klinikos were included. The patients were divided into three groups according to the spread of the disease: group 1 - patients with local NB older than 12 years of age; group 2 - stage IV patients, also called the M stage; group 3 - infants with stages 4S and MS. The patients were stratified into three risk groups - low, intermediate and high risk. Estimates of five-year overall survival (OS
resultsOverall 60 children (31 girls and 29 boys) with NB were included. The median age at diagnosis was 1.87 years (ranged from 4 days to 15 years). Seventy-eight percent of cases were found to be differentiated or undifferentiated NB, 22% - ganglioneuroblastoma. The local form of the disease was predominant: 57% (34/60) of patients were allocated to the group 1, 37% (22/60) with initial metastatic disease were assigned to group 2, and infants with 4S or MS stage comprising 7% (4/60) allocated to group 3, respectively. The probability of OS
conclusionsThere was a slight predominance of low-risk patients, probably due to a higher number of infants. A better probability of OS
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