Evidence map›Paper›PMID 28844698›Full record

ReviewTrends in genetics : TIG2017

Transposable Element Domestication As an Adaptation to Evolutionary Conflicts.

Diwash Jangam, Cédric Feschotte, Esther Betrán

Open access · greenAbstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers.

0numbers the graph read from it
0cells of the map it votes in
142citing papers in PubMed
51.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

142 citing papers in PubMed, 278 citations in OpenAlex.

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  20. From the genome's perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review

82 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Diwash JangamDepartment of Biology, University of Texas at Arlington, Arlington, TX, USA.
Cédric FeschotteDepartment of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA; Present address: Department of Molecular Biology and Genetics, Cornell University, Ithaca, NY, USA. Electronic address: cf458@cornell.edu.
Esther BetránDepartment of Biology, University of Texas at Arlington, Arlington, TX, USA. Electronic address: betran@uta.edu.
The University of Texas at Arlington · USCornell University · US

Funding

POPULATION GENETICS OF MOBILE ELEMENTSR01GM059290 · NIGMS · UNIVERSITY OF UTAH · PI BATZER, MARK A, FESCHOTTE, CEDRIC · 1999 to 2018
$8.5M
Genomic and Physiological Impact of Transposable Elements.R35GM122550 · NIGMS · CORNELL UNIVERSITY · PI Cedric Feschotte · 2017 to 2026
$4.4M
Connecting transposable elements and regulatory innovation using ENCODE dataU01HG009391 · NHGRI · WASHINGTON UNIVERSITY · PI COHEN, BARAK A, FESCHOTTE, CEDRIC · 2017 to 2021
$2.4M
Sexual conflict and relocation of genes by duplicationR01GM071813 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI BETRAN, ESTHER · 2005 to 2014
$1.5M
Human DNA transposons: evolutionary history and genomic impactR01GM077582 · NIGMS · UNIVERSITY OF UTAH · PI FESCHOTTE, CEDRIC · 2007 to 2015
$1.4M
Endogenous Retroviruses Co-Opted for Immune DefensesR01GM112972 · NIGMS · UNIVERSITY OF UTAH · PI FESCHOTTE, CEDRIC · 2015 to 2017
$804k
NHGRI NIH HHS U01 HG009391NIGMS NIH HHS R01 GM059290NIGMS NIH HHS R01 GM071813NIGMS NIH HHS R01 GM077582NIGMS NIH HHS R01 GM112972NIGMS NIH HHS R35 GM122550
6 · The paper itself

Abstract

Transposable elements (TEs) are selfish genetic units that typically encode proteins that enable their proliferation in the genome and spread across individual hosts. Here we review a growing number of studies that suggest that TE proteins have often been co-opted or 'domesticated' by their host as adaptations to a variety of evolutionary conflicts. In particular, TE-derived proteins have been recurrently repurposed as part of defense systems that protect prokaryotes and eukaryotes against the proliferation of infectious or invasive agents, including viruses and TEs themselves. We argue that the domestication of TE proteins may often be the only evolutionary path toward the mitigation of the cost incurred by their own selfish activities.

Indexed as

DNA Transposable ElementsEvolution, MolecularAdaptation, PhysiologicalHost-Pathogen InteractionsDNA Transposable Elementsadaptationevolutionary conflictstransposable element protein domestication

Identifiers

PMID28844698
PMCPMC5659911
OpenAlexW2748182739

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.