Evidence map›Paper›PMID 28844660›Full record

ArticleStem cell reports2017

Dermatopontin in Bone Marrow Extracellular Matrix Regulates Adherence but Is Dispensable for Murine Hematopoietic Cell Maintenance.

Ashley C Kramer, Amanda L Blake, Mandy E Taisto, Michael J Lehrke, Beau R Webber, Troy C Lund

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ashley C KramerDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Amanda L BlakeDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Mandy E TaistoDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Michael J LehrkeDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA.
Beau R WebberDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA; B-MoGen Biotechnologies, Inc., 614 McKinley Place NE, Minneapolis, MN 55413, USA.
Troy C LundDepartment of Pediatrics, Blood and Marrow Transplant Program, University of Minnesota Medical School, MMC 366, 420 Delaware Street SE, Minneapolis, MN 55455, USA. Electronic address: lundx072@umn.edu.
University of Minnesota Medical Center · US

Funding

TRAINING IN HEMOGLOBIN &CELL MEMBRANE RESEARCHT32HL007062 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller, Gregory M Vercellotti · 1985 to 2026
$10.3M
Perivascular Cell Characterization and Contribution to the Hematopoietic NicheK08HL108998 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUND, TROY C. · 2011 to 2015
$686k
Overcoming barriers to cellular traffickingR03HL133318 · NHLBI · UNIVERSITY OF MINNESOTA · PI LUND, TROY C. · 2016 to 2017
$152k
NHLBI NIH HHS K08 HL108998NHLBI NIH HHS R03 HL133318NHLBI NIH HHS T32 HL007062
6 · The paper itself

Abstract

The hematopoietic marrow microenvironment is composed of multiple cell types embedded in an extracellular matrix (ECM). We have explored marrow ECM using mass spectrometry and found dermatopontin (DPT), a small non-collagenous ECM protein, to be present. We found that DPT cooperates with other ECM proteins to promote hematopoietic cell adherence in vitro on plastic as well as OP9 stromal cells. We generated constitutional DPT

Indexed as

AnimalsBone MarrowCell AdhesionChondroitin Sulfate ProteoglycansExtracellular MatrixExtracellular Matrix ProteinsHematopoiesisHematopoietic Stem CellsMass SpectrometryMiceMice, KnockoutChondroitin Sulfate ProteoglycansDpt protein, mouseExtracellular Matrix Proteinsdecellularizationdermatopontinextracellular matrixhematopoiesishematopoietic niche

Identifiers

PMID28844660
PMCPMC5599243
OpenAlexW2749196530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.