Evidence map›Paper›PMID 28844659›Full record

ArticleStem cell reports2017

Recapitulation of Human Retinal Development from Human Pluripotent Stem Cells Generates Transplantable Populations of Cone Photoreceptors.

Anai Gonzalez-Cordero, Kamil Kruczek, Arifa Naeem, Milan Fernando, Magdalena Kloc, Joana Ribeiro, Debbie Goh, Yanai Duran, Samuel J I Blackford, Laura Abelleira-Hervas and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 153 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
153citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

153 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Autosomal RecessiveInternational journal of molecular sciences · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Transduction of AAV Vectors in iPSC-Derived Retinal Organoids.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  19. Article
  20. Article

93 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Anai Gonzalez-CorderoDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Kamil KruczekDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Arifa NaeemDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Milan FernandoDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Magdalena KlocDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Joana RibeiroDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Debbie GohDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Yanai DuranDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Samuel J I BlackfordDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Laura Abelleira-HervasDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Robert D SampsonDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Ian O ShumDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Matthew J BranchDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Peter J GardnerDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Jane C SowdenStem Cells and Regenerative Medicine Section, UCL Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.
James W B BainbridgeDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Alexander J SmithDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Emma L WestDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Rachael A PearsonDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK.
Robin R AliDepartment of Genetics, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK; NIHR Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, City Road, London EC1V 2PD, UK. Electronic address: r.ali@ucl.ac.uk.

Funding

Department of Health NIHR-RP-011-003Medical Research Council G0700089Medical Research Council MC_PC_15004Medical Research Council MR/J004553/1Medical Research Council MR/L012758/1Medical Research Council MR/M007871/1Medical Research Council MR/M015688/1Wellcome Trust
6 · The paper itself

Abstract

Transplantation of rod photoreceptors, derived either from neonatal retinae or pluripotent stem cells (PSCs), can restore rod-mediated visual function in murine models of inherited blindness. However, humans depend more upon cone photoreceptors that are required for daylight, color, and high-acuity vision. Indeed, macular retinopathies involving loss of cones are leading causes of blindness. An essential step for developing stem cell-based therapies for maculopathies is the ability to generate transplantable human cones from renewable sources. Here, we report a modified 2D/3D protocol for generating hPSC-derived neural retinal vesicles with well-formed ONL-like structures containing cones and rods bearing inner segments and connecting cilia, nascent outer segments, and presynaptic structures. This differentiation system recapitulates human photoreceptor development, allowing the isolation and transplantation of a pure population of stage-matched cones. Purified human long/medium cones survive and become incorporated within the adult mouse retina, supporting the potential of photoreceptor transplantation for treating retinal degeneration.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell DifferentiationCells, CulturedDisease Models, AnimalHuman Embryonic Stem CellsHumansPluripotent Stem CellsRetinal Cone Photoreceptor CellsRetinal DegenerationTime FactorsAdaptor Proteins, Signal TransducingAipl1 protein, mousecone photoreceptorsdifferentiationphotoreceptorretina and transplantationstem cells

Identifiers

PMID28844659
PMCPMC5599247

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.