ArticleMutation research. Genetic toxicology and environmental mutagenesis2017
Personal samplers of bioavailable pesticides integrated with a hair follicle assay of DNA damage to assess environmental exposures and their associated risks in children.
Article in Mutation research. Genetic toxicology and environmental mutagenesis, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03319927 (Reducing Pesticide Exposures to Preschool-age Children in California Child Care Centers), which is not on this map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Reducing Pesticide Exposures to Preschool-age Children in California Child Care Centers
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A systematic review of the use of silicone wristbands for environmental exposure assessment, with a focus on polycyclic aromatic hydrocarbons (PAHs).Journal of exposure science & environmental epidemiology · 2022Pooled it
- Knowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1-6 years from rural China.Environmental science and pollution research international · 2019Trial
- Not just splitting hairs-monitoring environmental chemical exposures, their biological effects and their social determinants with hair shafts and follicles: a narrative review.Environmental health : a global access science source · 2026Review
- Silicone Wristbands for Measuring Human Exposure to Organic Chemicals: Uses and Benefits for Human Biological Research.American journal of human biology : the official journal of the Human Biology Council · 2026Article
- Obesity increases DNA damage in the breast epithelium.Breast cancer research : BCR · 2025Article
- An Assessment of Multipollutant Exposures Using Silicone Wristbands Among Bangladeshi Youth.International journal of environmental research and public health · 2024Article
- Wristband Personal Passive Samplers and Suspect Screening Methods Highlight Gender Disparities in Chemical Exposures.Environmental science & technology · 2024Article
- The Effects of Environmental Pollutants and Exposures on Hair Follicle Pathophysiology.Skin appendage disorders · 2024Review
- Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities.Exposure and health · 2024Article
- Pesticide Exposure among Latinx Children in Rural Farmworker and Urban Non-Farmworker Communities: Associations with Locality and Season.International journal of environmental research and public health · 2023Article
- Exposures to pesticides and risk of cancer: Evaluation of recent epidemiological evidence in humans and paths forward.International journal of cancer · 2023Article
- Personal air pollutant exposure monitoring in South African children in the VHEMBE birth cohort.Environment international · 2022Article
- Silicone wristbands as personal passive sampling devices: Current knowledge, recommendations for use, and future directions.Environment international · 2022Review
- Evaluating predictive relationships between wristbands and urine for assessment of personal PAH exposure.Environment international · 2022Article
- Silicone Wristbands in Exposure Assessment: Analytical Considerations and Comparison with Other Approaches.International journal of environmental research and public health · 2022Review
- Comparative Assessment of Pesticide Exposures in Domestic Dogs and Their Owners Using Silicone Passive Samplers and Biomonitoring.Environmental science & technology · 2022Article
- Operationalizing the Exposome Using Passive Silicone Samplers.Current pollution reports · 2022Review
- Pesticide exposure among Latinx child farmworkers in North Carolina.American journal of industrial medicine · 2021Article
- Pesticide exposure among Latinx children: Comparison of children in rural, farmworker and urban, non-farmworker communities.The Science of the total environment · 2021Article
- Catching flame retardants and pesticides in silicone wristbands: Evidence of exposure to current and legacy pollutants in Uruguayan children.The Science of the total environment · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
Agriculture in the United States employs youth ages ten and older in work environments with high pesticide levels. Younger children in rural areas may also be affected by indirect pesticide exposures. The long-term effects of pesticides on health and development are difficult to assess and poorly understood. Yet, epidemiologic studies suggest associations with cancer as well as cognitive deficits. We report a practical and cost-effective approach to assess environmental pesticide exposures and their biological consequences in children. Our approach combines silicone wristband personal samplers and DNA damage quantification from hair follicles, and was tested as part of a community-based participatory research (CBPR) project involving ten Latino children from farmworker households in North Carolina. Our study documents high acceptance among Latino children and their caregivers of these noninvasive sampling methods. The personal samplers detected organophosphates, organochlorines, and pyrethroids in the majority of the participants (70%, 90%, 80%, respectively). Pesticides were detected in all participant samplers, with an average of 6.2±2.4 detections/participant sampler. DNA damage in epithelial cells from the sheath and bulb of plucked hairs follicles was quantified by immunostaining 53BP1-labled DNA repair foci. This method is sensitive, as shown by dose response analyses to γ radiations where the lowest dose tested (0.1Gy) led to significant increased 53BP1 foci density. Immunolabeling of DNA repair foci has significant advantages over the comet assay in that specific regions of the follicles can be analyzed. In this cohort of child participants, significant association was found between the number of pesticide detections and DNA damage in the papilla region of the hairs. We anticipate that this monitoring approach of bioavailable pesticides and genotoxicity will enhance our knowledge of the biological effects of pesticides to guide education programs and safety policies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.