Evidence map›Paper›PMID 28844150›Full record

ArticleAIDS research and human retroviruses2017

Evidence for Altered Glutamine Metabolism in Human Immunodeficiency Virus Type 1 Infected Primary Human CD4

Andrea Hegedus, Maia Kavanagh Williamson, Mariam B Khan, Julianna Dias Zeidler, Andrea T Da Poian, Tatiana El-Bacha, Eduard A Struys, Hendrik Huthoff

Open access · bronzeAbstract read
In one paragraph

Article in AIDS research and human retroviruses, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Metabolomics of HIV in the Modern cART Era.Advances in experimental medicine and biology · 2026
    Review
  7. Article
  8. Immuno-cell metabolic changes in HIV-1 infection.Infectious diseases & immunity · 2025
    Review
  9. Article
  10. Article
  11. Understanding Metabolic Pathway Rewiring by Oncogenic Gamma Herpesvirus.Journal of microbiology and biotechnology · 2024
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Andrea Hegedus1 Department of Infectious Diseases, King's College London , London, United Kingdom .
Maia Kavanagh Williamson1 Department of Infectious Diseases, King's College London , London, United Kingdom .
Mariam B Khan1 Department of Infectious Diseases, King's College London , London, United Kingdom .
Julianna Dias Zeidler2 Instituto de Bioquímica Médica Leopoldo de Meis , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil .
Andrea T Da Poian2 Instituto de Bioquímica Médica Leopoldo de Meis , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil .
Tatiana El-Bacha3 Instituto de Nutrição Josué de Castro , Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil .
Eduard A Struys4 Metabolic Unit, Department of Clinical Chemistry, VU Medical Center , Amsterdam, the Netherlands .
Hendrik Huthoff1 Department of Infectious Diseases, King's College London , London, United Kingdom .
King's College London · GBUniversidade Federal do Rio de Janeiro · BRAmsterdam UMC Location VUmc · NL

Funding

Medical Research Council MR/J008125/1Medical Research Council MR/M026213/1Medical Research Council MR/P502054/1
6 · The paper itself

Abstract

Glutamine is a conditionally essential amino acid that is an important metabolic resource for proliferating tissues by acting as a proteinogenic amino acid, a nitrogen donor for biosynthetic reactions and as a substrate for the citric acid or tricarboxylic acid cycle. The human immunodeficiency virus type 1 (HIV-1) productively infects activated CD4

Indexed as

CD4-Positive T-LymphocytesCell ProliferationCells, CulturedGlutamineHealthy VolunteersHIV-1HIV InfectionsHumansVirus ReplicationGlutamineCD4+ T cellsglutamic acidglutaminaseglutamineHIV-1metabolism

Identifiers

PMID28844150
PMCPMC5709700
OpenAlexW2761410950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.