SynthesisThe Korean journal of internal medicine2018
Use of hypnotics and the risk of or mortality from heart disease: a meta-analysis of observational studies.
Synthesis in The Korean journal of internal medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Benzodiazepines or related drugs and risk of cardiovascular diseases: a meta-analysis of cohort studies.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Zolpidem use and the risk of arrhythmia: A nationwide population-based cohort study in Taiwan.Journal of the Chinese Medical Association : JCMA · 2026Article
- Lifestyle medicine pillars for women's heart health.American journal of preventive cardiology · 2025Article
- Incidence and trend of cardiac events among children and young adults exposed to psychopharmacological treatment (2006-2018): A nationwide register-based study.British journal of clinical pharmacology · 2025Article
- Zolpidem-triggered atrial fibrillation in a patient with cardiomyopathy: a case report.BMC cardiovascular disorders · 2024Article
- Investigating the causal interplay between sleep traits and risk of acute myocardial infarction: a Mendelian randomization study.BMC medicine · 2023Article
- Gender differences in spontaneous adverse event reports associated with zolpidem in South Korea, 2015-2019.Frontiers in pharmacology · 2023Article
- Hypnotics Use Is Associated with Elevated Incident Atrial Fibrillation: A Propensity-Score Matched Analysis of Cohort Study.Journal of personalized medicine · 2022Article
- Trends, correlates, and disease patterns of sedative-hypnotic use among elderly persons in Taiwan.BMC psychiatry · 2022Article
- Management of chronic insomnia using hypnotics: a friend or a foe?Sleep and biological rhythms · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background/Aims: Some observational epidemiologic studies have reported conflicting results on the relationship between hypnotics use and the risk of developing and/or dying from heart disease. We investigated these associations using a meta-analysis of available literatures.
methodsWe searched the databases PubMed and EMBASE, along with the bibliographies of relevant articles to find additional publications in February 2016.
resultsOf 495 articles satisfying our initial criteria, two case-control studies and six cohort studies met our inclusion criteria and were included in the final analyses. Compared with never having used any kind of hypnotics, the odds ratio for overall use was 0.84 for risk of or mortality from heart disease (95% confidence interval, 0.79 to 0.89) in a random-effects meta-analysis of all eight studies. With respect to the geographical region, use of hypnotics was associated with a decreased risk or mortality of heart disease in Asia but not in Western countries. Among various types of sleep medications, zolpidem showed a decreased risk (-29%) of developing or dying from heart disease, but benzodiazepines were related with an increased risk (80%) of or mortality from heart disease. Conclusions: The current meta-analysis of observational epidemiological studies suggested an evidence of association between hypnotics use and a decreased risk of heart disease.
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