ArticlePediatric radiology2017
Long-term effects of radiation therapy on white matter of the corpus callosum: a diffusion tensor imaging study in children.
Article in Pediatric radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Advanced diffusion MRI tractography for radiotherapy planning in pediatric brain tumors: A feasibility study.Physics and imaging in radiation oncology · 2026Article
- Late-onset radiation-induced brain necrosis following allogeneic transplantation for CNS-involved acute myeloid leukemia after whole brain irradiation: two case reports.Blood science (Baltimore, Md.) · 2025Article
- Central Nervous System Response Against Ionizing Radiation Exposure: Cellular, Biochemical, and Molecular Perspectives.Molecular neurobiology · 2025Review
- White matter connectivity and social functioning in survivors of pediatric brain tumor.Journal of neuro-oncology · 2024Article
- Total-Body Irradiation Alters White Matter Volume and Microstructural Integrity in Rhesus Macaques.International journal of radiation oncology, biology, physics · 2024Article
- Advancing Beyond the Hippocampus to Preserve Cognition for Patients With Brain Metastases: Dosimetric Results From a Phase 2 Trial of Memory-Avoidance Whole Brain Radiation Therapy.Advances in radiation oncology · 2024Article
- High Radiation Dose to the Fornix Causes Symptomatic Radiation Necrosis in Patients with Anaplastic Oligodendroglioma.Yonsei medical journal · 2024Article
- Article
- Brain diffusion MRI biomarkers after oncology treatments.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Review
- Effects of Hippocampal Sparing Radiotherapy on Brain Microstructure-A Diffusion Tensor Imaging Analysis.Brain sciences · 2022Article
- Brain Damage and Patterns of Neurovascular Disorder after Ionizing Irradiation. Complications in Radiotherapy and Radiation Combined Injury.Radiation research · 2021Review
- Brain Imaging in Pediatric Cancer Survivors: Correlates of Cognitive Impairment.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2021Review
- Review
- Review
- Long-term cognitive outcome in adult survivors of an early childhood posterior fossa brain tumour.International journal of clinical oncology · 2020Article
- Proliferation of Bilateral Nerve Fibers Following Thalamic Infarction Contributes to Neurological Function Recovery: A Diffusion Tensor Imaging (DTI) Study.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- An initial report of memory avoidance whole brain radiotherapy to treat brain metastases.Neuro-oncology advancesArticle
- Watch-and-wait approach versus adjuvant treatment after radical awake resection in selected adult-type grade 3 gliomas,Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundDespite improving survival rates, children are at risk for long-term cognitive and behavioral difficulties following the diagnosis and treatment of a brain tumor. Surgery, chemotherapy and radiation therapy have all been shown to impact the developing brain, especially the white matter.
objectiveThe purpose of this study was to determine the long-term effects of radiation therapy on white matter integrity, as measured by diffusion tensor imaging, in pediatric brain tumor patients 2 years after the end of radiation treatment, while controlling for surgical interventions. MATERIALS AND
methodsWe evaluated diffusion tensor imaging performed at two time points: a baseline 3 to 12 months after surgery and a follow-up approximately 2 years later in pediatric brain tumor patients. A region of interest analysis was performed within three regions of the corpus callosum. Diffusion tensor metrics were determined for participants (n=22) who underwent surgical tumor resection and radiation therapy and demographically matched with participants (n=22) who received surgical tumor resection only.
resultsAnalysis revealed that 2 years after treatment, the radiation treated group exhibited significantly lower fractional anisotropy and significantly higher radial diffusivity within the body of the corpus callosum compared to the group that did not receive radiation.
conclusionThe findings indicate that pediatric brain tumor patients treated with radiation therapy may be at greater risk of experiencing long-term damage to the body of the corpus callosum than those treated with surgery alone.
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Registered trials
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