SynthesisThorax2018
Diagnostic accuracy of interleukin 27 for tuberculous pleural effusion: two prospective studies and one meta-analysis.
Synthesis in Thorax, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Pooled it
- Diagnostic Value of T-SPOT.TB Assay for Tuberculous Peritonitis: A Meta-Analysis.Frontiers in medicine · 2020Pooled it
- A Study Investigating Markers in PLeural Effusion (SIMPLE): a prospective and double-blind diagnostic study.BMJ open · 2019Trial
- Derivation and validation of a clinical prediction model incorporating the pleural fluid ADA-to-LDH ratio for differentiating tuberculous from malignant pleural effusions: a multi-center study.BMC pulmonary medicine · 2026Article
- A comprehensive diagnostic model for tuberculous PE: integration of clinical and immunological biomarkers.Frontiers in public health · 2026Article
- The role of the pleural fluid lactate dehydrogenase/adenosine deaminase ratio in differentiating between tuberculosis pleural effusion and parapneumonic effusion: a retrospective cohort study and meta-analysis.Journal of thoracic disease · 2025Article
- Pleural carbohydrate antigen 50 and malignant pleural effusion: a prospective, double-blind diagnostic accuracy test.Translational lung cancer research · 2024Article
- Pleural fluid soluble Fas ligand and tuberculous pleural effusion: a prospective diagnostic test accuracy study.Journal of thoracic disease · 2023Article
- Identification of immune biomarkers in recent active pulmonary tuberculosis.Scientific reports · 2023Article
- Comparison of proteomic landscape of extracellular vesicles in pleural effusions isolated by three strategies.Frontiers in bioengineering and biotechnology · 2023Article
- Hepatocyte growth factor combined with adenosine deaminase as biomarker for diagnosis of tuberculous pleural effusion.Frontiers in microbiology · 2023Article
- Diagnostic accuracy of pleural fluid lactate dehydrogenase to adenosine deaminase ratio for tuberculous pleural effusion: an analysis of two cohorts.BMC pulmonary medicine · 2022Article
- N-myc and STAT interactor is a novel biomarker of severity in community-acquired pneumonia: a prospective study.Respiratory research · 2022Observational
- Interleukin 32 as a Potential Marker for Diagnosis of Tuberculous Pleural Effusion.Microbiology spectrum · 2022Article
- Single-cell immune profiling reveals functional diversity of T cells in tuberculous pleural effusion.The Journal of experimental medicine · 2022Article
- Global trends of research on tuberculous pleurisy over the past 15 years: A bibliometric analysis.Frontiers in cellular and infection microbiology · 2022Article
- Pleural Fluid Soluble Interleukin-2 Receptor as a Biomarker for the Diagnosis of Tuberculosis Pleural Effusion: A Systematic Review and Meta-Analysis.Journal of tropical medicine · 2022Review
- Anaphylatoxins orchestrate Th17 response via interactions between CD16+ monocytes and pleural mesothelial cells in tuberculous pleural effusion.PLoS neglected tropical diseases · 2021Article
- Beware of Pleural Thickening and Calcification: An Enlightenment from a Case of Tuberculous Pleurisy.Risk management and healthcare policy · 2021Article
- Interleukin-27 and Its Diverse Effects on Bacterial Infections.Frontiers in immunology · 2021Review
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAccurate differentiating diagnosis is essential for choosing treatment for exudative pleural effusions.
objectiveTo establish the diagnostic accuracy of interleukin 27 for tuberculous pleural effusion (TPE).
methodsFirst, the concentrations of pleural interleukin 27, interferon-gamma and adenosine deaminase were compared between 51 patients with TPE and 103 with non-TPEs (Beijing cohort), and their diagnostic values were evaluated. These were further verified in another independent population (Wuhan cohort, n=120). In the second part of the study, we performed a meta-analysis.
resultsWith a cut-off value of 591.4 ng/L in the Beijing cohort, the area under the curve, sensitivity, specificity, positive predictive value and negative predictive value of interleukin 27 to diagnose TPE were 0.983 (95% CI 0.947 to 0.997), 96.1% (86.5% to 99.5%), 99.0% (94.7% to 100%), 98.0 (89.4 to 99.9) and 98.1 (93.3 to 99.8), respectively. Excellent diagnostic accuracy of interleukin 27 was also found in the Wuhan cohort and was further confirmed in the meta-analysis. The diagnostic performance of interleukin 27 was comparable to that of interferon-gamma and was more accurate than that of adenosine deaminase. Since the post-test probability of a negative result was always <0.1%, a negative test was considered to exclude TPE in all tuberculosis prevalence settings.
conclusionsInterleukin 27 can be used to diagnose TPE in a high prevalence setting, and a negative result can also be reliably used to rule out TPE in all prevalence settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.