Evidence map›Paper›PMID 28843903›Full record

ArticlePsychoneuroendocrinology2017

Amygdala volume and hypothalamic-pituitary-adrenal axis reactivity to social stress.

Tom J Barry, Lynne Murray, Pasco Fearon, Christina Moutsiana, Tom Johnstone, Sarah L Halligan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychoneuroendocrinology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 3 countries.

Tom J BarryDepartment of Psychology, The University of Hong Kong, Pokfulam Road, Hong Kong; Institute of Psychiatry, Psychology & Neuroscience, King's College London, London SE5 8AF, UK.
Lynne MurraySchool of Psychology and CLS, University of Reading, Reading RG6 6AL, UK; Department of Psychology, Stellenbosch University, Stellenbosch, South Africa; Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Pasco FearonResearch Department of Clinical, Educational and Health Psychology, University College London, 1-19 Torrington Place, London WC1E 7HB, UK.
Christina MoutsianaDepartment of Psychology, University of Westminster, 115 New Cavendish Street, London W1W 6UW, UK.
Tom JohnstoneSchool of Psychology and CLS, University of Reading, Reading RG6 6AL, UK.
Sarah L HalliganDepartment of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Department of Psychology, University of Bath, Bath BA2 7AY, UK. Electronic address: s.l.halligan@bath.ac.uk.
University of Reading · GBKing's College London · GBUniversity College London · GBUniversity of Bath · GBUniversity of Westminster · GB

Funding

Medical Research Council G0701514Medical Research Council G9324094
6 · The paper itself

Abstract

The amygdala plays a central role in emotional processing and has an activating influence on the hypothalamic-pituitary-adrenal (HPA) axis. Structural changes in the amygdala have been associated with early adversity and, in principle, may contribute to the later emergence of emotional pathologies by influencing the way that the brain responds to stress provocation. The present study examined the relationship between amygdala volumes and cortisol secretion in response to a social stressor among young adults who were or were not exposed to maternal postnatal depression (PND) early in development (referred to as PND offspring and controls, respectively). Hierarchical Linear Modelling (HLM) revealed that, on a sample-wide level, there was no evidence of a relationship between total amygdala volume, or the volume of the right or left hemisphere amygdala taken separately, and cortisol reactivity. Unexpectedly, for PND offspring, larger right hemisphere amygdala volume was associated with lower cortisol reactivity in response to stress, an effect that was not apparent in control offspring. We conclude that the relationship between amygdala volumes and stress reactivity may not be as clear as previous models suggested.

Indexed as

Child of Impaired ParentsDepression, PostpartumMothersAdultAmygdalaFemaleHumansHydrocortisoneHypothalamo-Hypophyseal SystemLongitudinal StudiesMalePituitary-Adrenal SystemStress, PsychologicalYoung AdultHydrocortisoneAmygdalaCortisolDepressionHypothalamic-pituitary-adrenal axisStress sensitivity

Identifiers

PMID28843903
PMCPMC5632999
OpenAlexW2738254931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.