Evidence map›Paper›PMID 28843850›Full record

ArticleComprehensive psychiatry2017

Substance use disorders in adolescent and young adult relatives of probands with bipolar disorder: What drives the increased risk?

Leslie A Hulvershorn, Jennifer King, Patrick O Monahan, Holly C Wilcox, Philip B Mitchell, Janice M Fullerton, Howard J Edenberg, Gloria M P Roberts, Masoud Kamali, Anne L Glowinski and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Comprehensive psychiatry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 9 institutions in 2 countries.

Leslie A HulvershornDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA. Electronic address: lhulvers@iupui.edu.
Jennifer KingDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Patrick O MonahanDepartment of Biostatistics, Indiana University School of Medicine Indianapolis, IN, USA.
Holly C WilcoxJohns Hopkins Schools of Medicine and Public Health, Baltimore, MD, USA.
Philip B MitchellSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.
Janice M FullertonNeuroscience Research Australia & School of Medical Sciences, University of New South Wales, Sydney, Australia.
Howard J EdenbergDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, USA.
Gloria M P RobertsSchool of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.
Masoud KamaliDepartment of Psychiatry and Depression Center, University of Michigan, Ann Arbor, MI, USA; Department of Psychiatry, Massachusetts General Hospital and Harvard University, Boston, MA.
Anne L GlowinskiDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.
Neera GhaziuddinChild and Adolescent Psychiatry, Depression Center, University of Michigan, Ann Arbor, MI.
Melvin McInnisDepartment of Psychiatry and Depression Center, University of Michigan, Ann Arbor, MI, USA.
Priya A Iyer-EimerbrinkSociology and Psychology Department, University of North Texas at Dallas, Dallas, TX, USA.
John I NurnbergerDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Indiana University School of MedicineIndiana University – Purdue University Indianapolis · USUniversity of Michigan–Ann Arbor · USUNSW Sydney · AUJohns Hopkins University · USMassachusetts General Hospital · USNeuroscience Research Australia · AUUniversity of North Texas at Dallas · USWashington University in St. Louis · US

Funding

AACAP Physician Scientist Program in Substance UseK12DA000357 · NIDA · AMERICAN ACADEMY-CHILD/ADOLESCENT PSYCH · PI Kevin M. Gray · 1998 to 2026
$29.1M
Adolescents at High Risk for Familial Bipolar DisorderR01MH068009 · NIMH · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI NURNBERGER, JOHN I · 2005 to 2009
$1.7M
Adolescents at High Risk for Familial Bipolar Disorder.R01MH068006 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MCINNIS, MELVIN G · 2005 to 2009
$1.4M
Adolescents at High Risk For Familial Bipolar DisorderR01MH073151 · NIMH · WASHINGTON UNIVERSITY · PI GLOWINSKI, ANNE L · 2005 to 2009
$1.3M
NIDA NIH HHS K12 DA000357NIMH NIH HHS R01 MH068006NIMH NIH HHS R01 MH068009NIMH NIH HHS R01 MH073151
6 · The paper itself

Abstract

backgroundAdults with bipolar disorder (BD) have higher rates of substance use disorders (SUDs) compared to the general population. SUD rates in young offspring/relatives of BD probands, as well as factors which drive those rates, are not as well-characterized.

methodsWe aimed to examine SUD prevalence among adolescent/young adult offspring and relatives of probands with and without BD. Data were collected from five sites in the US and Australia during 2006-2011. Youth offspring/relatives ("Relatives of BD probands;" n=267; mean age=16.8years; ±2.9S.D.), identified through a proband family member with DSM-IV BD (Type I or II), were compared to offspring/relatives of control probands ("relatives of control probands;" n=149; mean age=17.4years; ±2.9S.D.). Logistic regression with generalized estimating equations was used to compare the groups across a range of substance use and SUD variables. Odds ratios were calculated for lifetime prevalence of substance outcomes.

resultsBivariate analyses showed DSM-IV SUDs were more prevalent among relatives of BD probands than among relatives of control probands (29% vs. 18%; p=0.01). Generalized estimating equation models showed BD mood and childhood-onset externalizing disorders in adolescent and young adult relatives to each significantly increase the odds (OR=2.80-3.17; p<0.02) for the development of several substance variables among all relatives, whereas the risk of SUDs in relatives was not increased when the relatives had no mood or externalizing disorders themselves.

conclusionRelatives of BD probands with lifetime mood and externalizing disorders report more substance use/SUDs than relatives of control probands. In contrast, SUD outcomes in relatives of BD probands without mood or externalizing disorders were no different from control relatives without psychopathology. Early recognition and treatment of psychiatric disorders may lead to less substance use in this highly vulnerable population.

Indexed as

AdolescentAustraliaBipolar DisorderCase-Control StudiesChildFamilyFemaleHumansMalePrevalenceRisk FactorsSubstance-Related DisordersYoung Adult

Identifiers

PMID28843850
PMCPMC5647650
OpenAlexW2742015537

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.