Evidence map›Paper›PMID 28843831›Full record

ArticleJournal of controlled release : official journal of the Controlled Release Society2017

ImmunoPET imaging of tissue factor expression in pancreatic cancer with

Reinier Hernandez, Christopher G England, Yunan Yang, Hector F Valdovinos, Bai Liu, Hing C Wong, Todd E Barnhart, Weibo Cai

Abstract read
In one paragraph

Article in Journal of controlled release : official journal of the Controlled Release Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

  1. First-in-Humans PET Imaging of Tissue Factor in Patients with Primary and Metastatic Cancers UsingJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Trial
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Review
  8. Review
  9. Tissue Factor-Targeted ImmunoPET Imaging and Radioimmunotherapy of Anaplastic Thyroid Cancer.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020
    Article
  10. Molecular pharmaceutics · 2020
    Article
  11. Article
  12. Article
  13. Translational molecular imaging in exocrine pancreatic cancer.European journal of nuclear medicine and molecular imaging · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Reinier HernandezDepartment of Medical Physics, University of Wisconsin - Madison, WI 53705, USA.
Christopher G EnglandDepartment of Medical Physics, University of Wisconsin - Madison, WI 53705, USA.
Yunan YangDepartment of Radiology, University of Wisconsin - Madison, WI 53705, USA.
Hector F ValdovinosDepartment of Medical Physics, University of Wisconsin - Madison, WI 53705, USA.
Bai LiuAltor Bioscience Corporation, Miramar, FL 33025, USA.
Hing C WongAltor Bioscience Corporation, Miramar, FL 33025, USA.
Todd E BarnhartDepartment of Medical Physics, University of Wisconsin - Madison, WI 53705, USA.
Weibo CaiDepartment of Medical Physics, University of Wisconsin - Madison, WI 53705, USA; Department of Radiology, University of Wisconsin - Madison, WI 53705, USA; University of Wisconsin Carbone Cancer Center, Madison, WI 53792, USA. Electronic address: wcai@uwhealth.org.
University of Wisconsin–Madison · USAltor BioScience (United States) · US

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6M
BIOTECHNOLOGY TRAINING PROGRAMT32GM008349 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI FOX, BRIAN G · 1989 to 2019
$22.5M
U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Novel Combination Therapy for Prostate CancerR01CA169365 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CAI, WEIBO · 2013 to 2015
$903k
NCI NIH HHS P30 CA014520NCI NIH HHS R01 CA169365NCI NIH HHS T32 CA009206NIGMS NIH HHS T32 GM008349
6 · The paper itself

Abstract

Overexpression of tissue factor (TF) has been associated with increased tumor growth, tumor angiogenesis, and metastatic potential in many malignancies, including pancreatic cancer. Additionally, high TF expression was shown to strongly correlate with poor prognoses and decreased survival in pancreatic cancer patients. Herein, we exploited the potential targeting of TF for positron emission tomography (PET) imaging of pancreatic cancer. The TF-targeted tracer was developed through radiolabeling of the anti-human TF monoclonal antibody (ALT-836) with

Indexed as

DeferoxamineImmunoglobulin GRadioisotopesRadiopharmaceuticalsRecombinant ProteinsZirconiumAnimalsCell Line, TumorFemaleHumansKidneyLiverMice, NudePancreatic NeoplasmsPositron-Emission TomographySiderophoresALT-836DeferoxamineImmunoglobulin GRadioisotopesRadiopharmaceuticalsRecombinant ProteinsSiderophoresThromboplastinZirconiumZirconium-89(89)ZrALT-836immunoPETMolecular imagingPancreatic cancerPositron emission tomography (PET)Tissue factor (TF)

Identifiers

PMID28843831
PMCPMC5632593
OpenAlexW2749835380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.