ArticleBiomaterials2017
Multiscale design and synthesis of biomimetic gradient protein/biosilica composites for interfacial tissue engineering.
Article in Biomaterials, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 60 citations in OpenAlex.
- Strategies to control cellular spatial organization in microphysiological systems.Microsystems & nanoengineering · 2026Review
- Silk fibroin-based hydrogels for cartilage organoids in osteoarthritis treatment.Theranostics · 2025Review
- Gradient scaffolds in bone-soft tissue interface engineering: Structural characteristics, fabrication techniques, and emerging trends.Journal of orthopaedic translation · 2025Review
- Bioinspired gradient scaffolds for osteochondral tissue engineering.Exploration (Beijing, China) · 2023Review
- Biomedical applications of solid-binding peptides and proteins.Materials today. Bio · 2023Review
- Integrated gradient tissue-engineered osteochondral scaffolds: Challenges, current efforts and future perspectives.Bioactive materials · 2023Review
- Advanced silk materials for musculoskeletal tissue regeneration.Frontiers in bioengineering and biotechnology · 2023Review
- 3D-printed gradient scaffolds for osteochondral defects: Current status and perspectives.International journal of bioprinting · 2023Review
- Silk fibroin-based biomaterials for cartilage/osteochondral repair.Theranostics · 2022Review
- Engineering Natural and Recombinant Silks for Sustainable Biodevices.Frontiers in chemistry · 2022Review
- Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.Bioactive materials · 2021Review
- Structure of Animal Silks.Methods in molecular biology (Clifton, N.J.) · 2021Article
- 3D Bioprinting: from Benches to Translational Applications.Small (Weinheim an der Bergstrasse, Germany) · 2019Review
- Characterization and Cytotoxicity Evaluation of a Marine Sponge Biosilica.Marine biotechnology (New York, N.Y.) · 2019Article
- Design, Fabrication, and Function of Silk-Based Nanomaterials.Advanced functional materials · 2018Article
- Coding cell micropatterns through peptide inkjet printing for arbitrary biomineralized architectures.Advanced functional materials · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Continuous gradients present at tissue interfaces such as osteochondral systems, reflect complex tissue functions and involve changes in extracellular matrix compositions, cell types and mechanical properties. New and versatile biomaterial strategies are needed to create suitable biomimetic engineered grafts for interfacial tissue engineering. Silk protein-based composites, coupled with selective peptides with mineralization domains, were utilized to mimic the soft-to-hard transition in osteochondral interfaces. The gradient composites supported tunable mineralization and mechanical properties corresponding to the spatial concentration gradient of the mineralization domains (R5 peptide). The composite system exhibited continuous transitions in terms of composition, structure and mechanical properties, as well as cytocompatibility and biodegradability. The gradient silicified silk/R5 composites promoted and regulated osteogenic differentiation of human mesenchymal stem cells in an osteoinductive environment in vitro. The cells differentiated along the composites in a manner consistent with the R5-gradient profile. This novel biomimetic gradient biomaterial design offers a useful approach to meet a broad range of needs in regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.