SynthesisRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2017
Hypofractionated radiation therapy for basal and squamous cell skin cancer: A meta-analysis.
Synthesis in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07347392 (The Role of Radiotherapy for the Management of Non-melanoma Skin Cancer in Denmark), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Radiotherapy for the Management of Non-melanoma Skin Cancer in Denmark
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Hyperbaric oxygen therapy as an adjunct treatment of periodontitis, MRONJ, and ONJ: a systematic literature review.Clinical oral investigations · 2024Pooled it
- Skin CanceR Brachytherapy vs External beam radiation therapy (SCRiBE) meta-analysis.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2018Pooled it
- Expert opinion: radiotherapy for basal cell carcinoma : Recommendations from the DEGRO Dermatooncology Working Group.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Article
- Dosimetric evaluation of superficial radionuclide-based high-dose-rate brachytherapy for deep keratinocyte carcinoma: A case series.Journal of contemporary brachytherapy · 2026Article
- Article
- How Much Can Optimization of Hypofractionation Help to Reduce Carbon Equivalent Emissions? A Single-Center Modeling Study.Advances in radiation oncology · 2025Article
- High-dose-rate surface mold with tumor translucency brachytherapy for a 103-year-old patient with skin cancer, dementia, tremor, and kyphosis: a case report.Nagoya journal of medical science · 2025Article
- Palliative Radiotherapy to Preserve Eyesight in a Recurrent, Difficult-to-Treat Basal Cell Carcinoma.Cureus · 2025Article
- Radiobiology and modelling in Brachytherapy: A review inspired by the ESTRO Brachytherapy pre-meeting course.Clinical and translational radiation oncology · 2025Review
- Hypofractionated versus standard fractionation radiotherapy for merkel cell carcinoma.Radiation oncology (London, England) · 2024Article
- Cutaneous Squamous Cell Carcinoma in Patients with Solid-Organ-Transplant-Associated Immunosuppression.Cancers · 2024Review
- Review of recent advances in managing periocular skin malignancies.Frontiers in oncology · 2024Review
- Successful Treatment of Facial Merkel Cell Carcinoma Using CyberKnife Radiotherapy Alone: A Case Report.Cureus · 2023Article
- Article
- Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches.Molecular cancer · 2023Review
- Early clinical experience with a degraded 4 MeV electron beam in radiotherapy of superficial basal cell carcinoma.Physics and imaging in radiation oncology · 2023Article
- Long-term clinical outcomes of non-melanoma skin cancer patients treated with electronic brachytherapy.Journal of contemporary brachytherapy · 2023Article
- Review
- The State of the Art of Radiotherapy for Non-melanoma Skin Cancer: A Review of the Literature.Frontiers in medicine · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeTo characterize the cosmetic outcomes and local recurrence (LR) rates of various hypofractionated radiation therapy (RT) regimens for skin basal and squamous cell cancers (BCCs/SCCs).
methodsA PICOS/PRISMA/MOOSE selection protocol was performed to identify 344 articles published between 1985-2016 evaluating patients with T1-2 N0 SCCs/BCCs treated with definitive RT. Biologically equivalent doses with α/β=3 (BED
resultsA total of 21 studies were identified detailing the treatment of 9729 skin BCC/SCC patients, across seven countries, with external beam RT (n=9255) or brachytherapy (n=474). Median follow-up was 36months (range: 12-77). Median dose was 45Gy/11 fractions (interquartile range: 37.5Gy/6-55Gy/18) at 4Gy/fraction (interquartile range: 2.5-6Gy); most hypofractionated 18.75Gy/1. There was a trend to decreased "good" cosmesis with higher total dose: -3.4% "good" cosmesis/10Gy BED
conclusionHypofractionated RT has favorable cosmesis for patients with skin BCCs/SCCs. We recommend clinicians consider these commonly-used regimens, which all have BED
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