Evidence map›Paper›PMID 28843576›Full record

SynthesisThe Lancet. Infectious diseases2017

Effect of HSV-2 infection on subsequent HIV acquisition: an updated systematic review and meta-analysis.

Katharine J Looker, Jocelyn A R Elmes, Sami L Gottlieb, Joshua T Schiffer, Peter Vickerman, Katherine M E Turner, Marie-Claude Boily

Registry-linked trialOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Lancet. Infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05581160 (Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI), which is not on this map. Cited by 169 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
169citing papers in PubMed, 19 pooled it
15.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05581160 nacompletednot on this mapstarted 2022, after this paper: background citation

Assess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)

TypeinterventionalSponsorInstitut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'BaRan2022 to 2024Enrolled332ConditionsSexually Transmitted Infections (Not HIV or Hepatitis), Chlamydia Trachomatis Infection, Neisseria Gonorrhoeae Infection, Mycoplasma Genitalium InfectionArmsAssess the Performance of Metagenomic Sequencing in the Diagnosis of STI (NGS-IST)
3 · Its place in the literature

Who cites it

169 citing papers in PubMed, 19 syntheses or guidelines pooled it, 293 citations in OpenAlex.

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109 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Katharine J LookerSchool of Social and Community Medicine, University of Bristol, Bristol, UK. Electronic address: katharine.looker@bristol.ac.uk.
Jocelyn A R ElmesDepartment of Infectious Disease Epidemiology, Imperial College London, London, UK.
Sami L GottliebDepartment of Reproductive Health and Research, World Health Organization, Geneva, Switzerland.
Joshua T SchifferVaccine and Infectious Disease Division, and Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Department of Medicine, University of Washington, Seattle, WA, USA.
Peter VickermanSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Katherine M E TurnerBristol Veterinary School, University of Bristol, Bristol, UK.
Marie-Claude BoilyDepartment of Infectious Disease Epidemiology, Imperial College London, London, UK.
University of Bristol · GBImperial College London · GBUniversity of Washington · USWorld Health Organization · CH

Funding

SDMC: HPTN 084 Pregnancy SupplementUM1AI068617 · NIAID · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth Renata Brown, Deborah J Donnell · 2011 to 2026
$204.9M
THE PERINATAL COMPLICATIONS OF ASYMPTOMATIC GENITAL HERPES SIMPLEX VIRUSP01AI030731 · NIAID · UNIVERSITY OF WASHINGTON · PI WALD, ANNA · 1991 to 2017
$34.3M
Enhanced collaboration between US NIH and WHO on biomedical researchU01AI108543 · NIAID · WORLD HEALTH ORGANIZATION · PI TROEDSSON, HANS · 2013 to 2018
$3.7M
Modeling Structural HIV Determinants in Substance Users and related populationsR01DA037773 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MARTIN, NATASHA, STRATHDEE, STEFFANIE A. · 2015 to 2017
$1.4M
NIAID NIH HHS P01 AI030731NIAID NIH HHS U01 AI108543NIAID NIH HHS UM1 AI068617NIDA NIH HHS R01 DA037773Wellcome TrustWorld Health Organization 001
6 · The paper itself

Abstract

backgroundHIV and herpes simplex virus type 2 (HSV-2) infections cause a substantial global disease burden and are epidemiologically correlated. Two previous systematic reviews of the association between HSV-2 and HIV found evidence that HSV-2 infection increases the risk of HIV acquisition, but these reviews are now more than a decade old.

methodsFor this systematic review and meta-analysis, we searched PubMed, MEDLINE, and Embase (from Jan 1, 2003, to May 25, 2017) to identify studies investigating the risk of HIV acquisition after exposure to HSV-2 infection, either at baseline (prevalent HSV-2 infection) or during follow-up (incident HSV-2 infection). Studies were included if they were a cohort study, controlled trial, or case-control study (including case-control studies nested within a cohort study or clinical trial); if they assessed the effect of pre-existing HSV-2 infection on HIV acquisition; and if they determined the HSV-2 infection status of study participants with a type-specific assay. We calculated pooled random-effect estimates of the association between prevalent or incident HSV-2 infection and HIV seroconversion. We also extended previous investigations through detailed meta-regression and subgroup analyses. In particular, we investigated the effect of sex and risk group (general population vs higher-risk populations) on the relative risk (RR) of HIV acquisition after prevalent or incident HSV-2 infection. Higher-risk populations included female sex workers and their clients, men who have sex with men, serodiscordant couples, and attendees of sexually transmitted infection clinics.

findingsWe identified 57 longitudinal studies exploring the association between HSV-2 and HIV. HIV acquisition was almost tripled in the presence of prevalent HSV-2 infection among general populations (adjusted RR 2·7, 95% CI 2·2-3·4; number of estimates [N

interpretationWe found evidence that HSV-2 infection increases the risk of HIV acquisition. This finding has important implications for management of individuals diagnosed with HSV-2 infection, particularly for those who are newly infected. Interventions targeting HSV-2, such as new HSV vaccines, have the potential for additional benefit against HIV, which could be particularly powerful in regions with a high incidence of co-infection.

fundingWorld Health Organization.

Indexed as

Herpesvirus 2, HumanHerpes GenitalisHIV InfectionsHumansRisk Factors

Identifiers

PMID28843576
PMCPMC5700807
OpenAlexW2749420302

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.