SynthesisNeuroImage2017
Neuroanatomical foundations of delayed reward discounting decision making.
Synthesis in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Brain gray matter structures associated with trait impulsivity: A systematic review and voxel-based meta-analysis.Human brain mapping · 2021Pooled it
- Graph analysis uncovers an opposing impact of methylphenidate on connectivity patterns within default mode network sub-divisions.Behavioral and brain functions : BBF · 2024Trial
- Effects of prefrontal theta burst stimulation on neuronal activity and subsequent eating behavior: an interleaved rTMS and fNIRS study.Social cognitive and affective neuroscience · 2023Trial
- Identification of critical brain regions for young adults with obesity and their relationships with impulsivity using machine learning based on neuroanatomical features.International journal of obesity (2005) · 2026Article
- Garbage in, garbage out: stringent quality control of behavioral data boosts signal in brain-behavior associations.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Bias in Structural MRI Correlates of Delay Discounting due to Head Motion.Human brain mapping · 2026Article
- The nosology of addiction as a medical condition: a concise history and review of contemporary perspectives.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Alterations of gray matter asymmetry in internet gaming disorder.Scientific reports · 2024Article
- Multivariate analysis of multimodal brain structure predicts individual differences in risk and intertemporal preference.bioRxiv : the preprint server for biology · 2024Article
- Correspondence between the alcohol-P3 event-related potential and alcohol reward phenotypes among young adults.Alcohol, clinical & experimental research · 2024Article
- Discounting Future Reward in an Uncertain World.Decision (Washington, D.C.) · 2024Article
- Charting the brain networks of impulsivity: Meta-analytic synthesis, functional connectivity modelling, and neurotransmitter associations.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Reduced cortical complexity in ventromedial prefrontal cortex is associated with a greater preference for risky and immediate rewards.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Neurobiological metric of cortical delay discounting differentiates risk for self- and other-directed violence among trauma-exposed individuals.Journal of psychopathology and clinical science · 2023Article
- The intracortical myelin content of impulsive choices: results from T1- and T2-weighted MRI myelin mapping.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Development of a cortical delay discounting assay: a potential biomarker of externalizing disorders.Psychological medicine · 2023Article
- Investigating associations of delay discounting with brain structure, working memory, and episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Different topological patterns in structural covariance networks between high and low delay discounters.Frontiers in psychology · 2023Article
- Article
- A neural signature of the vividness of prospective thought is modulated by temporal proximity during intertemporal decision making.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Resolving tradeoffs between smaller immediate rewards and larger delayed rewards is ubiquitous in daily life and steep discounting of future rewards is associated with several psychiatric conditions. This form of decision-making is referred to as delayed reward discounting (DRD) and the features of brain structure associated with DRD are not well understood. The current study characterized the relationship between gray matter volume (GMV) and DRD in a sample of 1038 healthy adults (54.7% female) using cortical parcellation, subcortical segmentation, and voxelwise cortical surface-based group analyses. The results indicate that steeper DRD was significantly associated with lower total cortical GMV, but not subcortical GMV. In parcellation analyses, less GMV in 20 discrete cortical regions was associated with steeper DRD. Of these regions, only GMV in the middle temporal gyrus (MTG) and entorhinal cortex (EC) were uniquely associated with DRD. Voxelwise surface-based analyses corroborated these findings, again revealing significant associations between steeper DRD and less GMV in the MTG and EC. To inform the roles of MTG and EC in DRD, connectivity analysis of resting state data (N = 1003) using seed regions from the structural findings was conducted. This revealed that spontaneous activity in the MTG and EC was correlated with activation in the ventromedial prefrontal cortex, posterior cingulate cortex, and inferior parietal lobule, regions associated with the default mode network, which involves prospection, self-reflective thinking and mental simulation. Furthermore, meta-analytic co-activation analysis using Neurosynth revealed a similar pattern across 11,406 task-fMRI studies. Collectively, these findings provide robust evidence that morphometric characteristics of the temporal lobe are associated with DRD preferences and suggest it may be because of their role in mental activities in common with default mode activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.