SynthesisPharmacology, biochemistry, and behavior2018
Does being drunk or high cause HIV sexual risk behavior? A systematic review of drug administration studies.
Synthesis in Pharmacology, biochemistry, and behavior, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
52 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- Prevalence of mental health conditions among people living with HIV during the COVID-19 pandemic: A rapid systematic review and meta-analysis.HIV medicine · 2022Pooled it
- Measuring Sexual Risk-Taking: A Systematic Review of the Sexual Delay Discounting Task.Archives of sexual behavior · 2022Pooled it
- Sexual discounting: A systematic review of discounting processes and sexual behavior.Experimental and clinical psychopharmacology · 2021Pooled it
- Individual and poly-substance use and condomless sex among HIV-uninfected adults reporting heterosexual sex in a multi-site cohort.BMC public health · 2021Pooled it
- Relationships among impulsive, addictive and sexual tendencies and behaviours: a systematic review of experimental and prospective studies in humans.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2019Pooled it
- Systematic review of sex-based differences in opioid-based effects.International review of psychiatry (Abingdon, England) · 2018Pooled it
- Polysubstance use patterns and risk behaviors among people with cocaine use disorder.Experimental and clinical psychopharmacology · 2025Trial
- Causal Effects of Alcohol Consumption on Condom Negotiation Skills of Women with Varying Sexual Assault Histories.AIDS and behavior · 2025Trial
- External validity of analogue sexual risk laboratory data.Experimental and clinical psychopharmacology · 2023Trial
- Moderated Mediation of Perceived Intoxication and Sexual Arousal on Determinants of Sexual Risk Behavior in Men Who Have Sex with Men.AIDS and behavior · 2019Trial
- Sexual HIV risk behavior outcomes of brief interventions for drug use in an inner-city emergency department: Secondary outcomes from a randomized controlled trial.Drug and alcohol dependence · 2018Trial
- Sexual delay discounting as a moderator of the association between substance use and condomless anal sex among young black and Latino men who have sex with men.Addictive behaviors reports · 2026Article
- Differences in Patterns of Alcohol Use and Sexual Risk-Taking Behaviours Among Sexually Active Australian and Overseas-Born Domestic and International University Students in Australia.International journal of environmental research and public health · 2026Article
- Parent and friend support and communication as correlates of sexual and gender minority alcohol use in sexual contexts.Frontiers in psychology · 2026Article
- Sexually Transmitted Infection (STI) Incidence and Risk Factors Among People with HIV (PWH): Insights from a 13-Year Cohort Study in South Carolina.AIDS and behavior · 2025Article
- Psychosocial and behavioral factors associated with HIV among adolescent girls and young women in DREAMS districts in South Africa: cross-sectional survey.Frontiers in public health · 2025Article
- Acute ethanol disrupts conditioned inhibition in the male rat.Psychopharmacology · 2024Article
- Explaining the Relationship Between Intimate Partner Violence Victimization and Human Immunodeficiency Virus Status in Transgender and Nonbinary Individuals.Journal of interpersonal violence · 2024Article
- Patterns of Sexual Risk Behaviors and Sexuality-Related Risk Factors among Young Adults in Germany: Implications for Prevention and Therapy.Archives of sexual behavior · 2024Article
- PrEP for people who use opioids: A NIDA clinical trials network survey study in Southern U.S. cities where HIV incidence is high.Drug and alcohol dependence · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
HIV sexual risk behavior is broadly associated with substance use. Yet critical questions remain regarding the potential causal link between substance use (e.g., intoxication) and HIV sexual risk behavior. The present systematic review was designed to examine and synthesize the existing literature regarding the effects of substance administration on HIV sexual risk behavior. Randomized controlled experiments investigating substance administration and HIV sexual risk behavior (e.g., likelihood of condom use in a casual sex scenario) were included. Across five databases, 2750 titles/abstracts were examined and forty-three total peer reviewed published manuscripts qualified (few were multi-study manuscripts, and those details are outlined in the text). The majority of articles investigated the causal role of acute alcohol administration on HIV sexual risk behavior, although one article investigated the effects of acute THC administration, one the effects of acute cocaine administration, and two the effects of buspirone. The results of this review suggest a causal role in acute alcohol intoxication increasing HIV sexual risk decision-making. Although evidence is limited with other substances, cocaine administration also appears to increase sexual risk, while acute cannabis and buspirone maintenance may decrease sexual risk. In the case of alcohol intoxication, the pharmacological effects independently contribute to HIV sexual risk decision-making, and these effects are exacerbated by alcohol expectancies, increased arousal, and delay to condom availability. Comparisons across studies showed that cocaine led to greater self-reported sexual arousal than alcohol, potentially suggesting a different risk profile. HIV prevention measures should take these substance administration effects into account. Increasing the amount of freely and easily accessible condoms to the public may attenuate the influence of acute intoxication on HIV sexual risk decision-making.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.