Evidence map›Paper›PMID 28843294›Full record

ArticleThe Journal of investigative dermatology2017

Metabo-miR: miR-211 Regulates Mitochondrial Energy Metabolism in Vitiligo.

Vladimir S Spiegelman, Irina A Elcheva

Abstract readComment
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In one paragraph

Article in The Journal of investigative dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Epigenetic Modifications in Vitiligo.Clinical reviews in allergy & immunology · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Vladimir S SpiegelmanDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA. Electronic address: vspiegelman@pennstatehealth.psu.edu.
Irina A ElchevaDivision of Pediatric Hematology/Oncology, Department of Pediatrics, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania, USA.
Pennsylvania State University · US

Funding

RNA-binding protein CRD-BP in melanocyte biologyR01AR063361 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI SPIEGELMAN, VLADIMIR S. · 2013 to 2017
$1.6M
NIAMS NIH HHS R01 AR063361
6 · The paper itself

Abstract

The study by Sahoo et al. established miR-211 as a critical regulator of cellular metabolism in vitiligo cells. miR-211, which is expressed from the transient receptor potential melastatin 1 intronic region, regulates oxidative phosphorylation and mitochondrial energy metabolism in vitiligo. Loss of miR-211 in melanocytes was shown to alter expression patterns of newly identified target genes, and those that regulate respiratory functions in melanocytes are among them. This study highlights the importance of miR-211 for the melanocyte biology and development of vitiligo.

Indexed as

Gene Expression RegulationCells, CulturedEnergy MetabolismHumansMelanocytesMicroRNAsMitochondriaOxidative StressReactive Oxygen SpeciesSensitivity and SpecificitySignal TransductionVitiligoMicroRNAsReactive Oxygen Species

Identifiers

PMID28843294
OpenAlexW2747916731

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.