ArticleAsian Pacific journal of cancer prevention : APJCP2017
Moringa oleifera Root Induces Cancer Apoptosis more Effectively than Leave Nanocomposites and Its Free Counterpart
Article in Asian Pacific journal of cancer prevention : APJCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Biological properties ofF1000Research · 2024Pooled it
- Unveiling the anticancer potential of medicinal plants: metabolomics and analytical tools in phytomedicine.Molecular diversity · 2026Review
- Exploring the Therapeutic Potential ofInternational journal of molecular sciences · 2025Article
- Evaluation of Apoptosis and Caspase-3 Activity in EL4 Cell Line Lymphoma UsingArchives of Razi Institute · 2025Article
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- Photoactive metabolite mediated photodynamic therapy of Rhabdomyosarcoma cell lines using medicinal plants and Doxorubicin co-treatments.BMC complementary medicine and therapies · 2024Article
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- The use of African medicinal plants in cancer management.Frontiers in pharmacology · 2023Review
- Increasing the effect of annonacin using nanodiamonds to inhibit breast cancer cells growth in rats (Heliyon · 2022Article
- Immunological effect ofSaudi journal of biological sciences · 2022Article
- Inhibitory role of a smart nano-trifattyglyceride ofJournal of traditional and complementary medicine · 2021Article
- In Vitro Bioassay-Guided Identification of Anticancer Properties fromPharmaceuticals (Basel, Switzerland) · 2020Article
- Significant Decreased Expressions of CaN, VEGF, SLC39A6 and SFRP1 in MDA-MB-231 Xenograft Breast Tumor Mice Treated withNutrients · 2020Article
- Integration of medicinal plants into the traditional system of medicine for the treatment of cancer in Sokoto State, Nigeria.Heliyon · 2020Article
- Antioxidant and Anti-Inflammatory Properties of Cherry Extract: Nanosystems-Based Strategies to Improve Endothelial Function and Intestinal Absorption.Foods (Basel, Switzerland) · 2020Review
- Bioactive Components in Moringa Oleifera Leaves Protect against Chronic Disease.Antioxidants (Basel, Switzerland) · 2017Review
- A Review of the Phytochemical and Pharmacological Characteristics ofJournal of pharmacy & bioallied sciencesReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Medicinal plants are important elements of indigenous medical system that have persisted in developing countries. Many of the botanical chemo-preventions currently used as potent anticancer agents. However, some important anticancer agents are still extracted from plants because they cannot be synthesized chemically on a commercial scale due to their complex structures that often contain several chiral centers. The aim of this study was to test different extracts from the Moringa oleifera leaves (ML), its PLGA-CS-PEG nanocomposites (MLn), as well as root core (Rc) and outer (Ro) parts for activity against hepatocarcinoma HepG2, breast MCF7, and colorectal HCT 116/ Caco-2 cells in vitro. Nano-composites were prepared and characterized. Then, the nanocomposites and the free counterparts were screened on different propagated cancer cell lines. The underlying cytotoxic impact was followed using apoptosis measurements. All extracts kill the different cancer cells with different ratios, but intriguingly, the root core extract could kill the majority of cancer cells (approximately 70-80%), while sparing normal BHK-21 cells with minimal inhibitory effect (approximately 30-40%). Apoptotic cell increment came to confirm the cytotoxic effects of these extracts on HCT 116 cells (Rc: 212% and Ro: 180%, respectively) and HepG2 cells (ML: 567.5% and MLn: 608%, respectively) compared to control (100%) mechanistically wise. Moringa oleifera nanocomposites may have potential for use as a natural source of anti-cancer compounds.
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