ArticleAsian Pacific journal of cancer prevention : APJCP2017
Neem Seed Oil Induces Apoptosis in MCF-7 and MDA MB-231 Human Breast Cancer Cells
Article in Asian Pacific journal of cancer prevention : APJCP, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Modulatory Effect of Nimbin on Isoproterenol Induced Mitochondrial and Lysosomal Enzymes Activities and Apoptosis Signaling in Rats.Physiological research · 2025Article
- Biological Characterization, Properties, and Clinical Use of a Novel Homeopathic Antiseptic Oral Recovery Kit: A Narrative Review.Oral health & preventive dentistry · 2022Review
- Exploring the therapeutic potential of Neem (Annals of translational medicine · 2022Review
- High-throughput, Label-free Proteomics Identifies Salient Proteins and Genes in MDA-MB-231 Cells Treated with Natural Neem-based Electrochemotherapy.Applied biochemistry and biotechnology · 2022Article
- Characterization and phytochemical constituents of Periploca hydaspidis Falc crude extract and its anticancer activities.Saudi journal of biological sciences · 2021Article
- Total flavone extract from Ampelopsis megalophylla induces apoptosis in the MCF‑7 cell line.International journal of oncology · 2021Article
- Review
- Biogenic synthesis of silver nanoparticles: Antibacterial and cytotoxic potential.Saudi journal of biological sciences · 2020Article
- Potential of Regular Consumption of Cameroonian Neem (Evidence-based complementary and alternative medicine : eCAM · 2019Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In traditional Indian medicine, azadirachta indica (neem) is known for its wide range of medicinal properties. Various parts of neem tree including its fruit, seed, bark, leaves, and root have been shown to possess antiseptic, antiviral, antipyretic, anti-inflammatory, antiulcer, antimalarial, antifungal and anticancer activity. Materials and Methods: MCF-7 and MDA MB-231 cells were exposed to various concentrations of 2% ethanolic solution of NSO (1-30 μl/ml) and further processed for cell viability, cell cycle and apoptosis analysis. In addition, cells were analyzed for alteration in Mitochondrial Membrane Potential (MMP) and generation of Reactive Oxygen Species (ROS) using JC-1 and DCFDA staining respectively. Results: NSO give 50% inhibition at 10 μl/ml and 20 μl/ml concentration in MCF-7 and MDA MB-231 cells respectively and, arrests cells at G0/G1 phase in both the cell types. There was a significant alteration in mitochondrial membrane potential that leads to the generation of ROS and induction of apoptosis in NSO treated MCF-7 and MDA MB-231 cells. Conclusion: The results showed that NSO inhibits the growth of human breast cancer cells via induction of apoptosis and G1 phase arrest. Collectively these results suggest that NSO could potentially be used in the management of breast cancer.
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