Trial reportFish physiology and biochemistry2017
Effects of overfeeding and high-fat diet on cardiosomatic parameters and cardiac structures in young and adult zebrafish.
Trial report in Fish physiology and biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Impact of dietary composition on behavioural expression and gut microbiome dynamics in zebrafish.Pflugers Archiv : European journal of physiology · 2025Article
- Effects of Dietary Fish Oil Supplementation on the Growth, Proximate Composition, and Liver Health of Chinese Stripe-Necked Turtle (Animals : an open access journal from MDPI · 2024Article
- Differential Roles of Diet on Development and Spinal Cord Regeneration in Larval Zebrafish.Zebrafish · 2024Article
- Zebrafish Feed Intake: A Systematic Review for Standardizing Feeding Management in Laboratory Conditions.Biology · 2024Review
- High-fat diet feeding triggers a regenerative response in the adult zebrafish brain.Molecular neurobiology · 2023Article
- Research Progress on the Construction and Application of a Diabetic Zebrafish Model.International journal of molecular sciences · 2023Review
- The effects of an obesogenic diet on behavior and cognition in zebrafish (Ecology and evolution · 2022Article
- A zebrafish pparγ gene deletion reveals a protein kinase network associated with defective lipid metabolism.Functional & integrative genomics · 2022Article
- Zebrafish and Flavonoids: Adjuvants against Obesity.Molecules (Basel, Switzerland) · 2021Review
- Programming of Cardiovascular Dysfunction by Postnatal Overfeeding in Rodents.International journal of molecular sciences · 2020Review
- Influence of Commercial and Laboratory Diets on Growth, Body Composition, and Reproduction in the ZebrafishZebrafish · 2019Article
- Zebrafish as a Model for Obesity and Diabetes.Frontiers in cell and developmental biology · 2018Review
- Comparative Study of Different Diets-Induced NAFLD Models of Zebrafish.Frontiers in endocrinology · 2018Article
- Effects of Density and Food Availability on the Growth of Captive-Reared Eastern Hellbenders.Zoo biologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a complex global health problem because it is a risk factor for multiple chronic pathologies such as cardiovascular, endocrine, metabolic, and neoplastic diseases. It is considered a multicausal disease, and one of the determining factors is nutritional imbalances, which include high-fat diets. In this paper, we use the zebrafish model to assess the impact of overfeeding and a high-fat diet in somatic and cardiac parameters in young and adult zebrafish. The results show that fish receiving a high-fat diet showed greater weight gain compared to fish receiving a standard fat diet. Additionally, changes in the heart, including increases in size, a change in the triangular shape of the ventricle to a globular shape, and an increase in the thickness of the trabeculae of the spongy myocardium were observed. These changes could be indicators of cardiovascular overload. The results show that there is a direct relationship between the intake of a high-fat diet and obesity, which in turn can induce cardiac changes, supporting the hypothesis of the relationship between high-fat diets and cardiovascular risk factors. Given the genetic similarity between zebrafish and humans, these results could be extrapolated to human beings, and the findings similarly highlight the importance of incorporating a balanced diet from the early life stages to reduce the risk of cardiovascular disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.