Evidence map›Paper›PMID 28842733›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2017

Increasing alkali supplementation decreases urinary nitrogen excretion when adjusted for same day nitrogen intake.

L Ceglia, B Dawson-Hughes

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Acid-base balance of the diet-implications for bone and muscle.European journal of clinical nutrition · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

L CegliaNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA. lisa.ceglia@tufts.edu.
B Dawson-HughesNutrition, Exercise Physiology and Sarcopenia Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA.
Tufts University · US

Funding

Musculoskeletal benefits of bicarbonate in older adults - a dose-finding trialR01AR060261 · NIAMS · TUFTS UNIVERSITY BOSTON · PI DAWSON-HUGHES, BESS · 2011 to 2014
$1.7M
National Institute of Arthritis and Musculoskeletal and Skin Diseases 1RO1AR060261NIAMS NIH HHS R01 AR060261
6 · The paper itself

Abstract

We examined whether escalating doses of potassium bicarbonate (KHCO

introductionNeutralization of dietary acid load with alkali supplementation (i.e., KHCO

methodsWe evaluated changes in 24-h total urinary N excretion as a ratio of N excretion to concurrent N intake in 233 older men and women who participated in an 84-day KHCO

resultsAfter adjustment for relevant cofactors, escalating doses of KHCO

conclusionsUrinary N excretion expressed as ratio to same day N intake declined steadily with increasing doses of KHCO

trial registrationClinicaltrials.gov NCT1475214.

Indexed as

Dietary SupplementsAgedAnthropometryBicarbonatesDietDose-Response Relationship, DrugDouble-Blind MethodFemaleHumansMaleMiddle AgedMuscle ProteinsMuscle, SkeletalNitrogenPotassium CompoundsBicarbonatesMuscle ProteinsNitrogenpotassium bicarbonatePotassium CompoundsAlkaliNitrogen excretionPotassium bicarbonateSkeletal muscle

Identifiers

PMID28842733
PMCPMC6592622
OpenAlexW2748830693

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.