Evidence map›Paper›PMID 28842722›Full record

Trial reportDiabetologia2017

Glucose effectiveness, but not insulin sensitivity, is improved after short-term interval training in individuals with type 2 diabetes mellitus: a controlled, randomised, crossover trial.

Kristian Karstoft, Margaret A Clark, Ida Jakobsen, Sine H Knudsen, Gerrit van Hall, Bente K Pedersen, Thomas P J Solomon

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02320526 (Interval-training in Type 2 Diabetics - Mechanisms Behind Increased Glucose Disposal and Effects on Systemic Inflammation), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02320526 nacompletednot on this map

Interval-training in Type 2 Diabetics - Mechanisms Behind Increased Glucose Disposal and Effects on Systemic Inflammation

TypeinterventionalSponsorRigshospitalet, DenmarkRan2014 to 2016Enrolled14ConditionsDiabetes Mellitus, Type 2ArmsControl, Continuous walking, Interval walking
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Trial
  4. Gut Microbiota in Exercise-Regulated Development, Progression, and Management of Type 2 Diabetes Mellitus: A Review of the Role and Mechanisms.Medical science monitor : international medical journal of experimental and clinical research · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristian KarstoftThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, University of Copenhagen, Rigshospitalet, Section M7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. k_karstoft@dadlnet.dk.ORCID 0000-0002-6596-4199
Margaret A ClarkThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, University of Copenhagen, Rigshospitalet, Section M7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Ida JakobsenThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, University of Copenhagen, Rigshospitalet, Section M7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Sine H KnudsenThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, University of Copenhagen, Rigshospitalet, Section M7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Gerrit van HallClinical Metabolomics Core Facility, Clinical Biochemistry, Rigshospitalet, Department of Biomedical Sciences, Copenhagen, Denmark.
Bente K PedersenThe Centre of Inflammation and Metabolism and the Centre for Physical Activity Research, University of Copenhagen, Rigshospitalet, Section M7641, Blegdamsvej 9, DK-2100, Copenhagen, Denmark.
Thomas P J SolomonSchool of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aims/hypothesisThe role of glucose effectiveness (S

methodsFourteen participants with type 2 diabetes underwent three trials (IWT, CWT and no training) in a crossover study. Exclusion criteria were exogenous insulin treatment, smoking, pregnancy, contraindications to structured physical activity and participation in recurrent training (>90 min/week). The trials were performed in a randomised order (computerised-generated randomisation). IWT and CWT consisted of ten supervised treadmill walking sessions, each lasting 60 min, over 2 weeks. IWT was performed as repeated cycles of 3 min slow walking and 3 min fast walking (aiming for 54% and 89% of [Formula: see text], respectively, which was measured during the last minute of each interval), and CWT was performed aiming for a moderate walking speed (73% of [Formula: see text]). A two-step (pancreatic and hyperinsulinaemic) hyperglycaemic clamp was implemented before and after each trial. All data were collected in a hospitalised setting. Neither participants nor assessors were blinded to the trial interventions.

resultsThirteen individuals completed all procedures and were included in the analyses. IWT improved S CONCLUSIONS/

interpretationTwo weeks of IWT, but not CWT, improves S

trial registrationClinicalTrials.gov NCT02320526

fundingCFAS is supported by a grant from TrygFonden. During the study period, the Centre of Inflammation and Metabolism (CIM) was supported by a grant from the Danish National Research Foundation (DNRF55). The study was further supported by grants from Diabetesforeningen, Augustinusfonden and Krista og Viggo Petersens Fond. CIM/CFAS is a member of DD2-the Danish Center for Strategic Research in Type 2 Diabetes (the Danish Council for Strategic Research, grant no. 09-067009 and 09-075724).

Indexed as

AgedBlood GlucoseBody CompositionC-PeptideCross-Over StudiesDiabetes Mellitus, Type 2Energy MetabolismExerciseFemaleHumansInsulinInsulin ResistanceKineticsMaleMiddle AgedWalkingBlood GlucoseC-PeptideInsulinContinuous glucose monitoringExercise interventionsGlucose effectivenessHyperglycaemic clampHyperinsulinaemic clampInsulin sensitivityLifestyle intervention(s)Mass action of glucosePancreatic clampTraining

Identifiers

PMID28842722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.