ArticleScientific reports2017
Results from
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Chemical imaging unveils mitochondria as the major site of medicinal biguanide accumulation within cells.Heliyon · 2024Article
- Systematic review of antitumour efficacy and mechanism of metformin activity in prostate cancer models.BJUI compass · 2023Review
- Metabolic Action of Metformin.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Metformin, phenformin, and galegine inhibit complex IV activity and reduce glycerol-derived gluconeogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Metformin treatment of juvenile mice alters aging-related developmental and metabolic phenotypes.Mechanisms of ageing and development · 2022Article
- Review
- Article
- Review
- Cellular and Molecular Mechanisms of Metformin Action.Endocrine reviews · 2021Review
- Emerging strategies to target cancer metabolism and improve radiation therapy outcomes.The British journal of radiology · 2020Review
- Determination of metformin bio-distribution by LC-MS/MS in mice treated with a clinically relevant paradigm.PloS one · 2020Article
- Effects of metformin on tumor hypoxia and radiotherapy efficacy: a [EJNMMI research · 2019Article
- Pleiotropic Effects of Metformin on Cancer.International journal of molecular sciences · 2018Review
- Mitochondria in cancer metabolism, an organelle whose time has come?Biochimica et biophysica acta. Reviews on cancer · 2018Review
- Antidiabetic Biguanides Radiosensitize Hypoxic Colorectal Cancer Cells Through a Decrease in Oxygen Consumption.Frontiers in pharmacology · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation of hypoxia-induced radioresistance is gaining ground. Our cell studies confirm that biguanides inhibits cell proliferation by targeting respiration, but only at highly suprapharmacological concentrations due to low drug retention. Biodistribution/PET studies of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.