Evidence map›Paper›PMID 28842581›Full record

Trial reportScientific reports2017

A first-in-human study of the novel HIV-fusion inhibitor C34-PEG

Killian Quinn, Cinzia Traboni, Sujan Dily Penchala, Georgios Bouliotis, Nicki Doyle, Vincenzo Libri, Saye Khoo, Deborah Ashby, Jonathan Weber, Alfredo Nicosia and 3 more

Abstract readClinical Trial, Phase IRandomized Controlled Trial
In one paragraph

Trial report in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Killian QuinnDepartment of Medicine, Imperial College London, London, W2 1NY, UK.
Cinzia TraboniJV Bio, Via Gaetano Salvatore 486, 80145, Napoli, Italy.
Sujan Dily PenchalaDepartment of Pharmacology, University of Liverpool, Liverpool, L69 3BX, UK.
Georgios BouliotisSchool of Public Health, Imperial College London, London, UK.
Nicki DoyleDepartment of Medicine, Imperial College London, London, W2 1NY, UK.
Vincenzo LibriInstitute of Neurology, University College London, London, WC1N 3BG, UK.
Saye KhooDepartment of Pharmacology, University of Liverpool, Liverpool, L69 3BX, UK.
Deborah AshbySchool of Public Health, Imperial College London, London, UK.
Jonathan WeberDepartment of Medicine, Imperial College London, London, W2 1NY, UK.
Alfredo NicosiaJV Bio, Via Gaetano Salvatore 486, 80145, Napoli, Italy.
Riccardo CorteseJV Bio, Via Gaetano Salvatore 486, 80145, Napoli, Italy.
Antonello PessiJV Bio, Via Gaetano Salvatore 486, 80145, Napoli, Italy. a.pessi@peptipharma.it.ORCID 0000-0003-1298-2139
Alan WinstonDepartment of Medicine, Imperial College London, London, W2 1NY, UK. a.winston@imperial.ac.uk.

Funding

Medical Research Council MR/J002178/1
6 · The paper itself

Abstract

Long-acting injectable antiretroviral (LA-ARV) drugs with low toxicity profiles and propensity for drug-drug interactions are a goal for future ARV regimens. C34-PEG

Indexed as

AdolescentAdultAnimalsCells, CulturedCholesterolCohort StudiesDogsDouble-Blind MethodDrug Evaluation, PreclinicalDrug Resistance, ViralHIV-1HIV Envelope Protein gp41HIV Fusion InhibitorsHIV InfectionsHumansMale15-amino-4,7,10,13-tetraoxapentadecanoic acidCholesterolHIV Envelope Protein gp41HIV Fusion Inhibitorspeptide C34Peptide FragmentsPolyethylene GlycolsRecombinant Fusion Proteins

Identifiers

PMID28842581
PMCPMC5572697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.