Evidence map›Paper›PMID 28842505›Full record

ArticleThe Journal of biological chemistry2017

The glycosyltransferase GnT-III activates Notch signaling and drives stem cell expansion to promote the growth and invasion of ovarian cancer.

Heba Allam, Blake P Johnson, Mao Zhang, Zhongpeng Lu, Martin J Cannon, Karen L Abbott

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Glycosylation in Cancer.Handbook of experimental pharmacology · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Cells · 2022
    Article
  10. Peptide Sequence Mapping around Bisecting GlcNAc-BearingInternational journal of molecular sciences · 2021
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. The Journal of biological chemistry · 2020
    Article
  19. 3D Structure and Function of Glycosyltransferases Involved inInternational journal of molecular sciences · 2020
    Review
  20. The Roles of Glycans in Bladder Cancer.Frontiers in oncology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Heba AllamFrom the Medical Microbiology and Immunology Department, Menofiya University, Cairo 11795, Egypt.
Blake P Johnsonthe Department of Biology, Ouachita Baptist University, Arkadelphia, Arkansas 71998, and.
Mao Zhangthe Departments of Biochemistry and Molecular Biology and.
Zhongpeng Luthe Departments of Biochemistry and Molecular Biology and.
Martin J CannonObstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205.
Karen L Abbottthe Departments of Biochemistry and Molecular Biology and kabbott@uams.edu.
Ouachita Baptist University · USUniversity of Arkansas for Medical Sciences · US

Funding

Glycomics Laboratory for the Early Detection of Epithelial Ovarian CancerU01CA168870 · NCI · UNIV OF ARKANSAS FOR MED SCIS · PI ABBOTT, KAREN L. · 2012 to 2016
$2.0M
NCI NIH HHS U01 CA168870
6 · The paper itself

Abstract

Glycosylation changes associated with cellular transformation can facilitate the growth and progression of tumors. Previously we discovered that the gene

Indexed as

Signal TransductionAnimalsCarcinomaCell Line, TumorFemaleGlycosylationHumansKaplan-Meier EstimateMice, Inbred NODN-AcetylglucosaminyltransferasesNeoplasm InvasivenessNeoplasm ProteinsNeoplastic Stem CellsOvarian NeoplasmsOvaryProtein Processing, Post-Translationalbeta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferaseN-AcetylglucosaminyltransferasesNeoplasm ProteinsReceptors, NotchcancerglycosylationN-linked glycosylationNotch pathwayovarian cancer

Identifiers

PMID28842505
PMCPMC5625063
OpenAlexW2745643605

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.